Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Bcl11atm1.2Leid
Name:	BCL11 transcription factor A; targeted mutation 1.2, Mark Leid
MGI ID:	MGI:7506863
Synonyms:	Bcl11aL2, Bcl11atm1.2Akin
Gene:	Bcl11a  Location: Chr11:24028056-24124123 bp, + strand  Genetic Position: Chr11, 14.41 cM
Alliance:	Bcl11atm1.2Leid page

Germline Transmission:	Earliest citation of germline transmission: J:335842
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Conditional ready) Mutation:    Insertion   Mutation details: The first targeting vector is designed to insert loxP sites flanking exon 4 and an FRT-flanked neomycin cassette in reverse orientation downstream of exon 4. In this targeting event the upstream loxP site was lost. A second targeting event used the 129S2/SvPas-derived embryonic stem cells from the first targeting event and placed a LoxP-Hygro-LoxP upstream of exon 3, and generated mice with LoxP-Hygro-LoxP-Exon3 -Exon 4-LoxP. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination removed the hygro cassette. Exons 3 and 4 encode 75% of the protein coding sequence as well as the DNA binding domain. (J:335842)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bcl11a Mutation:	42 strains or lines available

Original:	J:335842 Bhattacharya N, et al., Selective Ablation of BCL11A in Epidermal Keratinocytes Alters Skin Homeostasis and Accelerates Excisional Wound Healing In Vivo. Cells. 2022 Jul 3;11(13)
All:	2 reference(s)