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Gene Expression Data
Assay Details
Assay
Reference: J:191149 Alves CH, et al., Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene. Hum Mol Genet. 2013 Jan 1;22(1):35-50
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7506776
Gene symbol: Crb2
Gene name: crumbs family member 2
Antibody: Anti-CRB2 SK11
Detection system: Secondary antibody coupled to Cy3
Results
Specimen 6A: embryonic day 18.5; Crb2tm1.1Wij/? (more )
Note: Controls could be Crb2F/F or Crb2F/+/Chx10Cre+/-.
Structure Level Pattern Image Note
TS26: retina Present Regionally restricted 6A Expression was detected in the subapical region.
Specimen 6B: embryonic day 18.5; Crb2tm1.1Wij/Crb2tm1.1Wij, Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: retina Absent 6B Some slight signal may be due to cross-reaction of the antibody.
Specimen S1A: embryonic day 11.5; Crb2tm1.1Wij/? (more )
Note: Controls could be Crb2F/F or Crb2F/+/Chx10Cre+/-.
Structure Level Pattern Image Note
TS19: neural retinal epithelium Present Regionally restricted S1A Expression was detected in the apical neuroepithelial layer.
Specimen S1D: embryonic day 11.5; Crb2tm1.1Wij/Crb2tm1.1Wij, Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: neural retinal epithelium Present Regionally restricted S1D , S1G Expression was detected in the apical neuroepithelial layer in the knockout.
Specimen S1J: embryonic day 12.5; Crb2tm1.1Wij/? (more )
Note: Controls could be Crb2F/F or Crb2F/+/Chx10Cre+/-.
Structure Level Pattern Image Note
TS20: retina Present Regionally restricted S1J Expression was detected in the subapical region.
Specimen S1M: embryonic day 12.5; Crb2tm1.1Wij/Crb2tm1.1Wij, Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: retina Trace S1M
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory