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Gene Expression Data
Assay Details
Assay
Reference: J:320312 Pitolli C, et al., Characterization of TG2 and TG1-TG2 double knock-out mouse epidermis. Amino Acids. 2017 Mar;49(3):635-642
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7505543
Gene symbol: Flg
Gene name: filaggrin
Antibody: anti-Filaggrin
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 2 WT: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: epidermis cornified layer Present 2_Filaggrin WT
TS26: epidermis granular layer Present 2_Filaggrin WT
Specimen 2 TG1KO: embryonic day 18.5; Tgm1tm1Kfyn/Tgm1tm1Kfyn (more )
Structure Level Pattern Image Note
TS26: epidermis granular layer Present Regionally restricted 2_Filaggrin TG1KO In this mutant expression and distribution was dispersed compared to wild-type.
TS26: epidermis cornified layer Present Regionally restricted 2_Filaggrin TG1KO Expression in this mutant showed that proteins were not correctly incorporated compared to wild-type.
Specimen 2 TG2KO: embryonic day 18.5; Tgm2tm1Gml/Tgm2tm1Gml (more )
Structure Level Pattern Image Note
TS26: epidermis cornified layer Present 2_Filaggrin TG2KO Expression in this mutant was the same as in wild-type.
TS26: epidermis granular layer Present 2_Filaggrin TG2KO Expression in this mutant was the same as in wild-type.
Specimen 2 TG1-TG2DKO: embryonic day 18.5; Tgm1tm1Kfyn/Tgm1tm1Kfyn, Tgm2tm1Gml/Tgm2tm1Gml (more )
Structure Level Pattern Image Note
TS26: epidermis granular layer Present Regionally restricted 2_Filaggrin TG1-TG2DKO In this mutant expression and distribution was dispersed compared to wild-type.
TS26: epidermis cornified layer Present Regionally restricted 2_Filaggrin TG1-TG2DKO Expression in this mutant showed that proteins were not correctly incorporated compared to wild-type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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