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Tg(SFTPC-SFTPA1*)T4Jflo
Transgene Detail
Summary
Symbol: Tg(SFTPC-SFTPA1*)T4Jflo
Name: transgene insertion T4, Joanna Floros
MGI ID: MGI:7493645
Synonyms: hTG SP-A1(6A4)
Transgene: Tg(SFTPC-SFTPA1*)T4Jflo  Location: unknown  
Alliance: Tg(SFTPC-SFTPA1*)T4Jflo page
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(SFTPC-SFTPA1*)T4Jflo expresses 1 gene
 
Mutation detailsThe transgenic construct contains the 3.7 kb human SFTPC (surfactant associated protein C) promoter, the 1.3 kb human SFTPA1 (surfactant associated protein A1) variant 6A4 coding sequence containing the 5' and 3' UTR and the entire coding region followed by an SV40 polyA signal. Founder line T4 (6A4) has low expression of the transgene. (J:161087)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:161087 Wang G, et al., Humanized SFTPA1 and SFTPA2 transgenic mice reveal functional divergence of SP-A1 and SP-A2: formation of tubular myelin in vivo requires both gene products. J Biol Chem. 2010 Apr 16;285(16):11998-2010
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory