Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Scn9aem1(icre)Itsu
Name:	sodium channel, voltage-gated, type IX, alpha; endonuclease-mediated mutation 1, Isao Tsuneyoshi
MGI ID:	MGI:7490200
Synonyms:	NaV1.7iCre, NaV1.7-iCre
Gene:	Scn9a  Location: Chr2:66310424-66465306 bp, - strand  Genetic Position: Chr2, 39.13 cM
Alliance:	Scn9aem1(icre)Itsu page

Strain of Origin:

C57BL/6J

Allele Type:    Endonuclease-mediated (Recombinase) Mutation:    Insertion   Scn9aem1(icre)Itsu expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Scn9a (MGI:107636)   Mutation details: Using the CRISPR/Cas9 system, a P2A-iCre-rabbit globin polyadenylation sequence was inserted after the last exon of the Scn9a gene. (J:330040)

Activity:	Tissue activity of this recombinase allele
Driver:	Scn9a (mouse) Summary of all recombinase alleles driven by Scn9a. Comparative matrix view of recombinase activities Alliance mouse Scn9a gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scn9a Mutation:	120 strains or lines available

Original:	J:330040 Maruta T, et al., Selective optogenetic activation of NaV1.7-expressing afferents in NaV1.7-ChR2 mice induces nocifensive behavior without affecting responses to mechanical and thermal stimuli. PLoS One. 2022;17(10):e0275751
All:	1 reference(s)