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Gene Expression Data
Assay Details
Assay
Reference: J:332246 Xie F, et al., N6-methyladenosine (m6A) RNA methylation mediated by methyltransferase complex subunit WTAP regulates amelogenesis. J Biol Chem. 2022 Dec;298(12):102715
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7490113
Gene symbol: Shh
Gene name: sonic hedgehog
Antibody: anti-SHH
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 4A: postnatal day 0.5; Wtaptm1c(EUCOMM)Hmgu/Wtaptm1c(EUCOMM)Hmgu (more )
Structure Level Pattern Image Note
TS27: inner enamel epithelium Present 4A
TS27: lower jaw incisor enamel organ Present 4A
Specimen 4B: postnatal day 0.5; Tg(KRT14-cre)1Amc/0, Wtaptm1c(EUCOMM)Hmgu/Wtaptm1c(EUCOMM)Hmgu (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: inner enamel epithelium Weak 4B Expression was significantly decreased in the mutant.
TS27: lower jaw incisor enamel organ Weak 4B Expression was significantly decreased in the mutant.
Specimen S5A: embryonic day 16.5; Wtaptm1c(EUCOMM)Hmgu/Wtaptm1c(EUCOMM)Hmgu (more )
Structure Level Pattern Image Note
TS24: inner enamel epithelium Present S5A
TS24: lower jaw molar enamel organ Present S5A
Specimen S5B: embryonic day 16.5; Tg(KRT14-cre)1Amc/0, Wtaptm1c(EUCOMM)Hmgu/Wtaptm1c(EUCOMM)Hmgu (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: inner enamel epithelium Present S5B Expression was significantly decreased in the mutant (quantified in S5C).
TS24: lower jaw molar enamel organ Present S5B Expression was significantly decreased in the mutant (quantified in S5C).
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory