Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Col10a1tm1.1(cre)Lyng
Name:	collagen, type X, alpha 1; targeted mutation 1.1, Liu Yang
MGI ID:	MGI:7490046
Synonyms:	Col10a1-CreA
Gene:	Col10a1  Location: Chr10:34265977-34273081 bp, + strand  Genetic Position: Chr10, 18.85 cM, cytoband B1-B3
Alliance:	Col10a1tm1.1(cre)Lyng page

Germline Transmission:	Earliest citation of germline transmission: J:324690
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Col10a1tm1.1(cre)Lyng expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Col10a1 (MGI:88445)   Mutation details: A cre recombinase gene and FRT-flanked neomycin resistance cassette were inserted at the translation initiation site in exon 2. Flp-mediated recombination removed the selection cassette as Col10a1tm2.1(cre)Ksec line described in J:122054. The recombination only took place in lower hypertrophic zone (HZ), which was delayed compared with that of Col10a1tm2.1(cre)Ksec line. (J:324690)

Activity:	Tissue activity of this recombinase allele
Driver:	Col10a1 (mouse) Summary of all recombinase alleles driven by Col10a1. Alliance mouse Col10a1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col10a1 Mutation:	27 strains or lines available

Original:	J:324690 Wang H, et al., Hedgehog signaling orchestrates cartilage-to-bone transition independently of Smoothened. Matrix Biol. 2022 Apr 23;
All:	1 reference(s)