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Gene Expression Data
Assay Details
Assay
Reference: J:79280 Kido Y, et al., Effects of Mutations in the Insulin-like Growth Factor Signaling System on Embryonic Pancreas Development and beta -Cell Compensation to Insulin Resistance. J Biol Chem. 2002 Sep 27;277(39):36740-7
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7489529
Gene symbol: Ins2
Gene name: insulin II
Antibody: anti-insulin
Results
Specimen 1a WT: embryonic day 18.5 (more )
Structure Cell Type Level Pattern Image Note
TS26: islets of Langerhans type B pancreatic cell Present 1a 10x WT , 1a 40x WT
Specimen 1a Insr-/-: embryonic day 18.5; Insrtm1Dac/Insrtm1Dac (more )
Structure Cell Type Level Pattern Image Note
TS26: islets of Langerhans type B pancreatic cell Present 1a 40x Insr-/- , 1a 10x Insr-/-
Specimen 1a Igf1r-/-: embryonic day 18.5; Igf1rtm1Arge/Igf1rtm1Arge (more )
Structure Cell Type Level Pattern Image Note
TS26: islets of Langerhans type B pancreatic cell Present 1a 40x Igf1r-/- , 1a 10x Igf1r-/-
Specimen 1a Insr-/-;Igf1r-/-: embryonic day 18.5; Igf1rtm1Arge/Igf1rtm1Arge, Insrtm1Dac/Insrtm1Dac (more )
Structure Cell Type Level Pattern Image Note
TS26: islets of Langerhans type B pancreatic cell Present 1a 40x Insr-/-;Igf1r-/- , 1a 10x Insr-/-;Igf1r-/- In this mutant the relative beta-cell area was increased about 3-fold, as a result of the decreased area of exocrine pancreas compared to wild-type.
Specimen 3a WT: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: islets of Langerhans Present 3a insulin WT
Specimen 3a Igf1-/-;Igf2+/p-: embryonic day 18.5; Igf1tm1Arge/Igf1tm1Arge, Igf2tm1Rob/Igf2+ (more )
Structure Level Pattern Image Note
TS26: islets of Langerhans Present 3a insulin Igf1-/-;Igf2+/p- This mutant has a decrease in exocrine pancreatic size compared to wild-type.
Specimen 5h wt: postnatal (more )
Structure Level Pattern Image Note
TS28: islets of Langerhans Present 5h wt
Specimen 5h ir+/-: postnatal; Insrtm1Dac/Insr+ (more )
Structure Level Pattern Image Note
TS28: islets of Langerhans Present 5h ir+/- In this mutant the islets were moderately enlarged and unevenly distributed compared to wild-type.
Specimen 5h igf1r+/-: postnatal; Igf1rtm1Arge/Igf1r+ (more )
Structure Level Pattern Image Note
TS28: islets of Langerhans Present 5h igf1r+/-
Specimen 5h ir+/-;igf1r+/-: postnatal; Igf1rtm1Arge/Igf1r+, Insrtm1Dac/Insr+ (more )
Structure Level Pattern Image Note
TS28: islets of Langerhans Present 5h ir+/-;igf1r+/- In this mutant the islets were moderately enlarged and unevenly distributed compared to wild-type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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