Tg(CD2-TGFBR2*)1Mbl
Transgene Detail
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| Symbol: |
Tg(CD2-TGFBR2*)1Mbl |
| Name: |
transgene insertion 1, Manfred Blessing |
| MGI ID: |
MGI:7488522 |
| Synonyms: |
dnTGF-betaR2, TgN(CD2kTRII)1Mbl |
| Transgene: |
Tg(CD2-TGFBR2*)1Mbl Location: unknown
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| Alliance: |
Tg(CD2-TGFBR2*)1Mbl page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(CD2-TGFBR2*)1Mbl expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
TGFBR2 (7048) |
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Tg(CD2-TGFBR2*)1Mbl expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Cd4 (MGI:88335) |
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Mutation details: The cDNA of a truncated TGFbeta type II receptor, which lacks the intracellular kinase domain, was placed under the control of the human CD2 promoter. The CD2 promoter/enhancer drives the copy number-dependent expression in T cells.
(J:82485)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:82485 Schramm C, et al., Impairment of TGF-beta signaling in T cells increases susceptibility to experimental autoimmune hepatitis in mice. Am J Physiol Gastrointest Liver Physiol. 2003 Mar;284(3):G525-35 |
| All: |
4 reference(s) |
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Analysis Tools
