Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Crybb1em1(icre)Cln
Name:	crystallin, beta B1; endonuclease-mediated mutation 1, Marco Colonna
MGI ID:	MGI:7488430
Synonyms:	Crybb1-Cre
Gene:	Crybb1  Location: Chr5:112403686-112417451 bp, + strand  Genetic Position: Chr5, 54.63 cM
Alliance:	Crybb1em1(icre)Cln page

Strain of Origin:

Not Applicable

Allele Type:    Endonuclease-mediated (Null/knockout, Recombinase) Mutations:    Insertion, Intragenic deletion   Crybb1em1(icre)Cln expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Crybb1 (MGI:104992)   Mutation details: Using CRISPR/Cas9 endonuclease-mediated genome editing, a codon-optimized iCre and polyA sequences replaced the exon 1 of the crystallin, beta B1 (Crybb1) gene on chromosome 5. (J:334326)

Activity:	Tissue activity of this recombinase allele
Driver:	Crybb1 (mouse) Summary of all recombinase alleles driven by Crybb1. Comparative matrix view of recombinase activities Alliance mouse Crybb1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Crybb1 Mutation:	9 strains or lines available

Original:	J:334326 Brioschi S, et al., A Cre-deleter specific for embryo-derived brain macrophages reveals distinct features of microglia and border macrophages. Immunity. 2023 Feb 8;
All:	1 reference(s)