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Gene Expression Data
Assay Details
Assay
Reference: J:167305 Sims-Lucas S, et al., Fgfr1 and the IIIc isoform of Fgfr2 play critical roles in the metanephric mesenchyme mediating early inductive events in kidney development. Dev Dyn. 2011 Jan;240(1):240-9
Assay type: RNA in situ
MGI Accession ID: MGI:7488156
Gene symbol: Six2
Gene name: sine oculis-related homeobox 2
Probe: Six2 probe
Probe preparation: Antisense labelled with digoxigenin RNA
Assay notes: Controls were littermates.
Results
Specimen 6B: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: metanephric mesenchyme Strong 6B
Specimen 6E: embryonic day 10.5; Fgfr1tm1Jpa/Fgfr1tm1Jpa, Fgfr2tm3.1Lni/Fgfr2tm3.1Lni, Tg(Pax3-cre)1Joe/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: metanephric mesenchyme Strong 6E Expression in this mutant is similar to controls. The mutant metanephric mesenchyme appears generally smaller.
Specimen 7B: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: metanephric mesenchyme Present 7B
Specimen 7E: embryonic day 11.5; Fgfr1tm1Jpa/Fgfr1tm1Jpa, Fgfr2tm3.1Lni/Fgfr2tm3.1Lni, Tg(Pax3-cre)1Joe/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: limb Present 7E
TS19: metanephric mesenchyme Absent 7E
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory