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Gene Expression Data
Assay Details
Assay
Reference: J:63415 Peng J, et al., The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8386-91
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7486571
Gene symbol: Pecam1
Gene name: platelet/endothelial cell adhesion molecule 1
Antibody: MEC 13.3
Detection system: Secondary antibody coupled to horseradish peroxidase
Results
Specimen 3A: embryonic day 11.5; Epas1tm1Fong/Epas1+ (more )
Structure Level Pattern Image Note
TS19: yolk sac blood vessel Present Regionally restricted 3A Highly organized vascular tree pattern.
Specimen 3B: embryonic day 11.5; Epas1tm1Fong/Epas1tm1Fong (more )
Structure Level Pattern Image Note
TS19: yolk sac blood vessel Present Regionally restricted 3B Vascular pattern differs from normal control only slightly when viewed at the whole-mount level, even in a severely hemorrhagic yolk sac.
Specimen 3C: embryonic day 11.5; Epas1tm1Fong/Epas1+ (more )
Structure Level Pattern Image Note
TS19: yolk sac blood vessel Present Regionally restricted 3C Endothelial cells form intact ring (tubular) structures.
Specimen 3D: embryonic day 11.5; Epas1tm1Fong/Epas1tm1Fong (more )
Structure Level Pattern Image Note
TS19: yolk sac blood vessel Present Regionally restricted 3D Endothelial cells form extended endothelial sheets without proper lumen structures.
Specimen 3E: embryonic day 11.5; Epas1tm1Fong/Epas1+ (more )
Structure Level Pattern Image Note
TS19: yolk sac blood vessel Present Regionally restricted 3E Endothelial cells form intact ring (tubular) structures.
Specimen 3F: embryonic day 11.5; Epas1tm1Fong/Epas1tm1Fong (more )
Structure Level Pattern Image Note
TS19: yolk sac blood vessel Present Regionally restricted 3F Endothelial cells form extended endothelial sheets without proper lumen structures.
Specimen 3G: embryonic day 11.5; Epas1tm1Fong/Epas1tm1Fong (more )
Structure Level Pattern Image Note
TS19: yolk sac blood vessel Present Regionally restricted 3G No significant vascular disorganization in moderately hemorrhaging mutants.
Specimen 3H: embryonic day 11.5; Epas1tm1Fong/Epas1tm1Fong (more )
Structure Level Pattern Image Note
TS19: yolk sac blood vessel Present Regionally restricted 3H No significant vascular disorganization in moderately hemorrhaging mutants.
Specimen 4A: embryonic day 9.5; Epas1tm1Fong/Epas1+ (more )
Structure Level Pattern Image Note
TS15: yolk sac blood vessel Present 4A
Specimen 4B: embryonic day 9.5; Epas1tm1Fong/Epas1tm1Fong (more )
Structure Level Pattern Image Note
TS15: yolk sac blood vessel Present Regionally restricted 4B Essentially normal vascular patterns at level of whole mount even in most severely hemorrhagic yolk sacs.
Specimen 4C: embryonic day 9.5; Epas1tm1Fong/Epas1+ (more )
Structure Level Pattern Image Note
TS15: yolk sac blood vessel Present 4C
Specimen 4D: embryonic day 9.5; Epas1tm1Fong/Epas1tm1Fong (more )
Structure Level Pattern Image Note
TS15: yolk sac blood vessel Present Regionally restricted 4D Disorganized vessels with very long endothelial linings
Specimen 4E: embryonic day 9.5; Epas1tm1Fong/Epas1+ (more )
Structure Level Pattern Image Note
TS15: yolk sac blood vessel Present 4E
Specimen 4F: embryonic day 9.5; Epas1tm1Fong/Epas1tm1Fong (more )
Structure Level Pattern Image Note
TS15: yolk sac blood vessel Present Regionally restricted 4F Occasional large openings in areas with active remodeling to form larger vessels,
Specimen 5A: embryonic day 9.5; Epas1tm1Fong/Epas1tm1Fong (more )
Structure Level Pattern Image Note
TS15: yolk sac blood vessel Present Regionally restricted 5A Severe vascular disorganization with adjacent vessels fusing to form large cavities lined by endothelial cells.
Specimen 5B: embryonic day 11.5; Epas1tm1Fong/Epas1tm1Fong (more )
Structure Level Pattern Image Note
TS19: yolk sac blood vessel Present Regionally restricted 5B Yolk sac vasculature grossly disorganized.
Specimen 5C: embryonic day 9.5; Epas1tm1Fong/Epas1tm1Fong (more )
Structure Level Pattern Image Note
TS15: yolk sac blood vessel Present Regionally restricted 5C Elongated endothelial linings and enlarged vascular lumen.
Specimen 5D: embryonic day 11.5; Epas1tm1Fong/Epas1tm1Fong (more )
Structure Level Pattern Image Note
TS19: yolk sac blood vessel Present Regionally restricted 5D Lumen enlargement appears to be caused by merging of adjacent vessels.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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01/28/2026
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