Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Gas1em1(icre/ERT2)Nono
Name:	growth arrest specific 1; endonuclease-mediated mutation 1, Noriaki Ono
MGI ID:	MGI:7484373
Synonyms:	Gas1-creER
Gene:	Gas1  Location: Chr13:60322219-60325179 bp, - strand  Genetic Position: Chr13, 31.92 cM, cytoband B3-C2
Alliance:	Gas1em1(icre/ERT2)Nono page

Strain of Origin:

(C57BL/6J x SJL/J)F1

Allele Type:    Endonuclease-mediated (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Gas1em1(icre/ERT2)Nono expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Gas1 (MGI:95655)   Mutation details: using CRISPR/Cas9 endonuclease-mediated genome editing, P2A-iCreERT2-bGH polyA sequences were inserted into the 3' UTR region of the growth arrest specific 1 (Gas1) gene on chromosome 13. (J:335639)

Activity:	Tissue activity of this recombinase allele
Driver:	Gas1 (mouse) Summary of all recombinase alleles driven by Gas1. Comparative matrix view of recombinase activities Alliance mouse Gas1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gas1 Mutation:	14 strains or lines available

Original:	J:335639 Matsushita Y, et al., Bone marrow endosteal stem cells dictate active osteogenesis and aggressive tumorigenesis. Nat Commun. 2023 Apr 25;14(1):2383
All:	1 reference(s)