Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tigitem1(cre/ERT2)Tebi
Name:	T cell immunoreceptor with Ig and ITIM domains; endonuclease-mediated mutation 1, Takashi Ebihara
MGI ID:	MGI:7484293
Synonyms:	Tigit-Cre-ERT2
Gene:	Tigit  Location: Chr16:43469230-43484509 bp, - strand  Genetic Position: Chr16, 28.44 cM
Alliance:	Tigitem1(cre/ERT2)Tebi page

Germline Transmission:	Earliest citation of germline transmission: J:335476
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Endonuclease-mediated (Inducible, Recombinase) Mutation:    Insertion   Tigitem1(cre/ERT2)Tebi expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Tigit (MGI:3642260)   Mutation details: The IRES-EGFP-Cre-ERT2 cassette was inserted into the 3' untranslated region of the Tigit gene in 129 ES cells by CRISPR/Cas9 method. (J:335476)

Activity:	Tissue activity of this recombinase allele
Driver:	Tigit (mouse) Summary of all recombinase alleles driven by Tigit. Comparative matrix view of recombinase activities Alliance mouse Tigit gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tigit Mutation:	31 strains or lines available

Original:	J:335476 Yamada T, et al., TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy. J Exp Med. 2023 Jul 3;220(7)
All:	1 reference(s)