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Gene Expression Data
Assay Details
Assay
Reference: J:238636 Fededa JP, et al., MicroRNA-34/449 controls mitotic spindle orientation during mammalian cortex development. EMBO J. 2016 Nov 15;35(22):2386-2398
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7482539
Gene symbol: Tbr1
Gene name: T-box brain transcription factor 1
Antibody: anti-TBR1
Results
Specimen 3E Het: embryonic day 14.0; Mir34atm1.1Aven/Mir34a+, Mirc21tm1.1Aven/Mirc21+, Mirc34tm1.1Cxu/Mirc34+ (more )
Note: Heterozygous littermate control mice were used but the specific genotype for specimen shown was not detailed.
Structure Cell Type Level Pattern Image Note
TS22: neocortex neuron of the forebrain Present Regionally restricted 3E Het Expression in neurons of layer IV.
Specimen 3E KO: embryonic day 14.0; Mir34atm1.1Aven/Mir34atm1.1Aven, Mirc21tm1.1Aven/Mirc21tm1.1Aven, Mirc34tm1.1Cxu/Mirc34tm1.1Cxu (more )
Note: Double (DKO) and triple (TKO) knockout littermates were grouped in this study. The specific genotype of the specimen shown was not reported. Embryos may or may not have expressed the Mir34a wild type allele.
Structure Level Pattern Image Note
TS22: neocortex Weak Regionally restricted 3E KO Significantly reduced number of expressing cells compared to control.
Specimen EV3B Het: embryonic day 14.0; Mir34atm1.1Aven/Mir34a+, Mirc21tm1.1Aven/Mirc21+, Mirc34tm1.1Cxu/Mirc34+ (more )
Note: Heterozygous littermate control mice were used but the specific genotype for specimen shown was not detailed.
Structure Level Pattern Image Note
TS22: neocortex Present Regionally restricted EV3B TBR1 Het Expression in neurons of layer IV.
Specimen EV3B KO: embryonic day 14.0; Mir34atm1.1Aven/Mir34atm1.1Aven, Mirc21tm1.1Aven/Mirc21tm1.1Aven, Mirc34tm1.1Cxu/Mirc34tm1.1Cxu (more )
Note: Double (DKO) and triple (TKO) knockout littermates were grouped in this study. The specific genotype of the specimen shown was not reported. Embryos may or may not have expressed the Mir34a wild type allele.
Structure Level Pattern Image Note
TS22: neocortex Weak Regionally restricted EV3B TBR1 KO Significantly reduced number of expressing cells compared to control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/14/2024
MGI 6.23 		The Jackson Laboratory