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Gene Expression Data
Assay Details
Assay
Reference: J:335425 Derbyshire ML, et al., Loss of Tbx3 in Mouse Eye Causes Retinal Angiogenesis Defects Reminiscent of Human Disease. Invest Ophthalmol Vis Sci. 2023 May 1;64(5):1
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7482272
Gene symbol: Eomes
Gene name: eomesodermin
Antibody: anti-Eomes/Tbr2 (ab23345)
Detection system: Secondary antibody coupled to Alexa Fluor 555
Results
Specimen 1K: postnatal day 2; Tbx3tm2.1Moon/Tbx3+ (more )
Note: Double labeled: red - Eomes (Tbr2); green - Tbx3 reporter (assay MGI:7482268).
Structure Cell Type Level Pattern Image Note
TS27: retina ganglion cell layer retinal ganglion cell Present Regionally restricted 1K (merge) , 1K Tbr2 Expression in intrinsically photosensitive retinal ganglion cells (ipRGCs).
Specimen 7A: postnatal day 0; Tbx3tm3.1Moon/Tbx3+ (more )
Structure Cell Type Level Pattern Image Note
TS27: retina ganglion cell layer retinal ganglion cell Present Regionally restricted 7A Expression in early intrinsically photosensitive retinal ganglion cells (ipRGCs).
Specimen 7B: postnatal day 0; Tbx3tm3.1Moon/Tbx3tm3.1Moon, Tg(Dkk3-cre)D9Tfur/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: retina ganglion cell layer retinal ganglion cell Weak Regionally restricted 7B Significant decrease in retinal ganglion cells compared to wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory