Tg(CAG-cre/ERT2/Hif1a)#Heh
Transgene Detail
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| Symbol: |
Tg(CAG-cre/ERT2/Hif1a)#Heh |
| Name: |
transgene insertion, Hannelore Ehrenreich |
| MGI ID: |
MGI:7482230 |
| Synonyms: |
CAG-CreERT2-ODD |
| Transgene: |
Tg(CAG-cre/ERT2/Hif1a)#Heh Location: unknown
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| Alliance: |
Tg(CAG-cre/ERT2/Hif1a)#Heh page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Inducible, Recombinase) |
| Inducer: |
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tamoxifen and hypoxia |
| Mutation: |
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Insertion
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Tg(CAG-cre/ERT2/Hif1a)#Heh expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| chicken |
CAG |
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Mutation details: The transgene containing the CAG promoter that drives ubiquitous expression of the tamoxifen-inducible cre recombinase gene (cre/ERT2) fused with the oxygen-dependent degradation (ODD) domain of Hif1a. This transgene is responsive to hypoxia. Under normoxic conditions, the ODD is hydroxylated by prolylhydroxylases, which tag HIF-1 upon binding of Von Hippel-Lindau (VHL) protein for proteasomal degradation. Hypoxic conditions lead to the inactivation of these enzymes and thus stabilization of HIF-1, allowing it to accumulate in the nucleus and activate the transcription of its target genes. The pound symbol (#) is used when no line is specified and/or lines are pooled.
(J:335577)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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CAG
(chicken)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:335577 Butt UJ, et al., Hippocampal neurons respond to brain activity with functional hypoxia. Mol Psychiatry. 2021 Jun;26(6):1790-1807 |
| All: |
1 reference(s) |
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Analysis Tools
