Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Camk2a-cre/ERT2/Hif1a)#Heh
Name:	transgene insertion, Hannelore Ehrenreich
MGI ID:	MGI:7481236
Synonyms:	CamkIIa-CreERT2-ODD
Transgene:	Tg(Camk2a-cre/ERT2/Hif1a)#Heh  Location: unknown
Alliance:	Tg(Camk2a-cre/ERT2/Hif1a)#Heh page

Strain of Origin:

Not Specified

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen and hypoxia Mutation:    Insertion   Tg(Camk2a-cre/ERT2/Hif1a)#Heh expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Camk2a (MGI:88256)   Mutation details: The transgene containing the murine Camk2a promoter drives expression of the tamoxifen-inducible cre recombinase gene (cre/ERT2) fused with the oxygen-dependent degradation (ODD) domain of Hif1a. This transgene is responsive to hypoxia. Under normoxic conditions, the ODD is hydroxylated by prolylhydroxylases, which tag HIF-1 upon binding of Von Hippel-Lindau (VHL) protein for proteasomal degradation. Hypoxic conditions lead to the inactivation of these enzymes and thus stabilization of HIF-1, allowing it to accumulate in the nucleus and activate the transcription of its target genes. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:322009)

Activity:	Tissue activity of this recombinase allele
Driver:	Camk2a (mouse) Summary of all recombinase alleles driven by Camk2a. Comparative matrix view of recombinase activities Alliance mouse Camk2a gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:322009 Butt UJ, et al., CaMKIIalpha Expressing Neurons to Report Activity-Related Endogenous Hypoxia upon Motor-Cognitive Challenge. Int J Mol Sci. 2021 Mar 20;22(6)
All:	1 reference(s)