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Gene Expression Data
Assay Details
Assay
Reference: J:324710 Stanton-Turcotte D, et al., Mllt11 Regulates Migration and Neurite Outgrowth of Cortical Projection Neurons during Development. J Neurosci. 2022 May 11;42(19):3931-3948
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7470806
Gene symbol: Cux1
Gene name: cut-like homeobox 1
Antibody: anti-Cux1/CDP
Detection system: Secondary antibody coupled to Alexa Fluor 568
Results
Specimen 2D Ctrl: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: cerebral cortex Present 2D Ctrl
Specimen 2D cKO: embryonic day 14.5; Mllt11tm1c(KOMP)Mbp/Mllt11tm1c(KOMP)Mbp, Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Cux2tm1.1(cre)Mull/Cux2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS22: cerebral cortex Present 2D cKO Largely normal compared with the control.
Specimen 2E Ctrl: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: cerebral cortex Present 2E Ctrl
Specimen 2E cKO: embryonic day 16.5; Mllt11tm1c(KOMP)Mbp/Mllt11tm1c(KOMP)Mbp, Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Cux2tm1.1(cre)Mull/Cux2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: cerebral cortex Present 2E cKO The numbers of positive cells began to decrease.
Specimen 2F Ctrl: embryonic day 18.5 (more )
Structure Cell Type Level Pattern Image Note
TS26: cerebral cortex cerebral cortex pyramidal neuron Present Regionally restricted 2F Ctrl Expressed in the corticocortical cortical projection neurons of layer 2/3.
Specimen 2F cKO: embryonic day 18.5; Mllt11tm1c(KOMP)Mbp/Mllt11tm1c(KOMP)Mbp, Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Cux2tm1.1(cre)Mull/Cux2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS26: cerebral cortex Present 2F cKO Severely decreased numbers of positive cells and an apical shift, compared with the control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory