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Tg(APOL1)G0Mrpk
Transgene Detail
Summary
Symbol: Tg(APOL1)G0Mrpk
Name: transgene insertion G0, Martin R Pollak
MGI ID: MGI:7469477
Synonyms: APOL1G0, hAPOL1_G0_BAC tg
Transgene: Tg(APOL1)G0Mrpk  Location: unknown  Genetic Position: Chr4, Syntenic
Alliance: Tg(APOL1)G0Mrpk page
Mutation
origin
Strain of Origin:  FVB/NJ
Mutation
description
Allele Type:    Endonuclease-mediated (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation details: CRISPR-targeting of Tg(APOL1*I384M)G0Mrpk reverted the mutation at codon 384 to the G0 haplotype (E150, I228, and K255). (J:322919)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:322919 McCarthy GM, et al., Recessive, gain-of-function toxicity in an APOL1 BAC transgenic mouse model mirrors human APOL1 kidney disease. Dis Model Mech. 2021 Aug 1;14(8):dmm048952
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory