Tg(APOL1*E150K)G2multiMrpk
Transgene Detail
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| Symbol: |
Tg(APOL1*E150K)G2multiMrpk |
| Name: |
transgene insertion G2multi, Martin R Pollak |
| MGI ID: |
MGI:7469467 |
| Synonyms: |
APOL1G2multi |
| Transgene: |
Tg(APOL1*E150K)G2multiMrpk Location: unknown
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| Alliance: |
Tg(APOL1*E150K)G2multiMrpk page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Mutation details: The transgene contains a human library clone (CTD2333M18) with 100,104 bp clone contained the APOL1 gene about 25 kB of upstream (including exons 1-5 of the APOL2 gene) and about 65 kB of downstream (including exons 4-41 of the MYH9 gene) sequence. The APOL1 sequence includes the amino acids K150, I228, and K255, which is identical to an alternate G0 haplotype. G2multi contains another copy of the transgene with an unknown integration site.
(J:322919)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:322919 McCarthy GM, et al., Recessive, gain-of-function toxicity in an APOL1 BAC transgenic mouse model mirrors human APOL1 kidney disease. Dis Model Mech. 2021 Aug 1;14(8):dmm048952 |
| All: |
1 reference(s) |
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Analysis Tools
