Tg(APOL1*E150K)G0altMrpk
Transgene Detail
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| Symbol: |
Tg(APOL1*E150K)G0altMrpk |
| Name: |
transgene insertion G0alt, Martin R Pollak |
| MGI ID: |
MGI:7469461 |
| Synonyms: |
APOL1G0alt |
| Transgene: |
Tg(APOL1*E150K)G0altMrpk Location: unknown Genetic Position: ChrUN, Syntenic
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| Alliance: |
Tg(APOL1*E150K)G0altMrpk page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Mutation details: The transgene contains a human library clone (CTD2333M18) with 100,104 bp clone contained the APOL1 gene about 25 kB of upstream (including exons 1-5 of the APOL2 gene) and about 65 kB of downstream (including exons 4-41 of the MYH9 gene) sequence. The APOL1 sequence includes the amino acids K150, I228, and K255, which is identical to an alternate G0 haplotype.
(J:322919)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:322919 McCarthy GM, et al., Recessive, gain-of-function toxicity in an APOL1 BAC transgenic mouse model mirrors human APOL1 kidney disease. Dis Model Mech. 2021 Aug 1;14(8):dmm048952 |
| All: |
1 reference(s) |
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Analysis Tools
