Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(APOL1*)G1Mrpk
Name:	transgene insertion G1, Martin R Pollak
MGI ID:	MGI:7469462
Synonyms:	APOL1G1
Transgene:	Tg(APOL1*)G1Mrpk  Location: unknown  Genetic Position: Chr4, Syntenic
Alliance:	Tg(APOL1*)G1Mrpk page

Strain of Origin:

FVB/NJ

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Mutation details: The transgene contains a human library clone (CTD2333M18) with 100,104 bp clone contained the APOL1 gene about 25 kB of upstream (including exons 1-5 of the APOL2 gene) and about 65 kB of downstream (including exons 4-41 of the MYH9 gene) sequence. The APOL1 G0 sequence was modified to include the amino acids E150, I228, and K255, which is identical to the G1 haplotype. (J:322919)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:322919 McCarthy GM, et al., Recessive, gain-of-function toxicity in an APOL1 BAC transgenic mouse model mirrors human APOL1 kidney disease. Dis Model Mech. 2021 Aug 1;14(8):dmm048952
All:	1 reference(s)