Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Mcoln3tm1.1(cre)Lrcb
Name:	mucolipin 3; targeted mutation 1.1, Christian Grimm
MGI ID:	MGI:7469457
Synonyms:	Trpml3IRES-Cre
Gene:	Mcoln3  Location: Chr3:145823205-145847561 bp, + strand  Genetic Position: Chr3, 71.03 cM
Alliance:	Mcoln3tm1.1(cre)Lrcb page

Germline Transmission:	Earliest citation of germline transmission: J:320955
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Mcoln3tm1.1(cre)Lrcb expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Mcoln3 (MGI:1890500)   Mutation details: The IRES-Cre-PGK-Neomycin cassette was inserted at 5 bp after the stop codon in exon 12 of the Mcoln3 (Trpml3) gene. The resulting mice were crossed with FLP deleter mice to remove the neo cassette. (J:320955)

Activity:	Tissue activity of this recombinase allele
Driver:	Mcoln3 (mouse) Summary of all recombinase alleles driven by Mcoln3. Comparative matrix view of recombinase activities Alliance mouse Mcoln3 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mcoln3 Mutation:	35 strains or lines available

Original:	J:320955 Spix B, et al., Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice. Nat Commun. 2022 Jan 14;13(1):318
All:	1 reference(s)