Tg(Gt(ROSA)26Sor-Ncre/vvd*,-vvd*/Ccre)2Tofu
Transgene Detail
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| Symbol: |
Tg(Gt(ROSA)26Sor-Ncre/vvd*,-vvd*/Ccre)2Tofu |
| Name: |
transgene insertion 2, Toshihiko Fujimori |
| MGI ID: |
MGI:7468982 |
| Synonyms: |
ROSA26-PA-Cre, Tg(Gt(ROSA)26Sor-cre*)2Tofu |
| Transgene: |
Tg(Gt(ROSA)26Sor-Ncre/vvd*,-vvd*/Ccre)2Tofu Location: unknown
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| Alliance: |
Tg(Gt(ROSA)26Sor-Ncre/vvd*,-vvd*/Ccre)2Tofu page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Inducible, Recombinase) |
| Inducer: |
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blue light exposure |
| Mutation: |
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Insertion
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Tg(Gt(ROSA)26Sor-Ncre/vvd*,-vvd*/Ccre)2Tofu expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Gt(ROSA)26Sor (MGI:104735) |
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Mutation details: The transgene consists of 2xcHS4(chicken b-globin insulator)-ROSA26 promoter-splicing acceptor-CreN59-nMag-Nuclear localization signal-2PA-Nuclear localization signal-pMag-CreC60-poly A sequence-2xcHS4r(chicken b-globin insulator). The nMag and pMag are part of Magnets protein derived from the fragments of photoreceptor gene product Vivid (VVD) from a filamentous fungi Neurospora crassa. This transgene contains photo-switchable magnet proteins which can reassemble split Cre proteins by light-induced dimerization when exposed to blue light. Four of the six founder lines showed light-dependent Cre-mediated DNA recombination and line 2 was established.
(J:320899)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Gt(ROSA)26Sor
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:320899 Kishi K, et al., Repetitive short-pulsed illumination efficiently activates photoactivatable-Cre as continuous illumination in embryonic stem cells and pre-implantation embryos of transgenic mouse. Genesis. 2021 Dec;59(12):e23457 |
| All: |
1 reference(s) |
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Analysis Tools
