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Gene Expression Data
Assay Details
Assay
Reference: J:40188 Chin JR, et al., Matrix metalloproteinases regulate morphogenesis, migration and remodeling of epithelium, tongue skeletal muscle and cartilage in the mandibular arch. Development. 1997 Apr;124(8):1519-30
Assay type: RNA in situ
MGI Accession ID: MGI:7468823
Gene symbol: Timp3
Gene name: tissue inhibitor of metalloproteinase 3
Probe: mTIMP-3 cDNA
Probe preparation: Antisense labelled with S35 RNA
Results
Specimen 4E: embryonic day 12.0 (more )
Structure Level Pattern Image Note
TS20: mandible primordium Strong Regionally restricted 4E Intense expression in mesenchyme in pre-osteoid region of lateral processes of branchial arch.
TS20: tongue Strong Regionally restricted 4E Intense expression along medial axis of tongue.
Specimen E13 not shown: embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: lower jaw mesenchyme Present Regionally restricted Expression in mesenchyme surrounding Meckel's cartilage, incisors, osteoid and perichondrium.
TS21: tongue intrinsic muscle Present Regionally restricted Expression in muscles of tongue proper and genioglossus muscle
TS21: Meckel's cartilage Absent
TS21: tooth mesenchyme Absent No expression in dental papilla.
TS21: nasal epithelium Absent
TS21: oral region epithelium Absent
TS21: tongue epithelium Absent
Specimen 4F: embryonic day 14.0 (more )
Structure Level Pattern Image Note
TS22: lower jaw mesenchyme Present Regionally restricted 4F Expression in mesenchyme surrounding incisor. Expression in osteoid surrounding incisors.
TS22: tongue intrinsic muscle Present 4F Expression in muscles of tongue proper.
TS22: genioglossus Present 4F
TS22: Meckel's cartilage Absent 4F
TS22: lower jaw incisor dental papilla Absent 4F
Specimen 4G: embryonic day 14.0 (more )
Structure Level Pattern Image Note
TS22: lower jaw mesenchyme Present Regionally restricted 4G Expression in mesenchyme surrounding Meckel's cartilage, incisors, osteoid and perichondrium.
TS22: Meckel's cartilage Absent 4G
TS22: lower jaw incisor dental papilla Absent 4G
Specimen E14 not shown: embryonic day 14.0 (more )
Structure Level Pattern Image Note
TS22: nasal epithelium Absent
TS22: oral region epithelium Absent
TS22: tongue epithelium Absent
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory