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Gene Expression Data
Assay Details
Assay
Reference: J:77122 Li S, et al., Hearing loss caused by progressive degeneration of cochlear hair cells in mice deficient for the Barhl1 homeobox gene. Development. 2002 Jul;129(14):3523-32
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:7467356
Gene symbol: Barhl1
Gene name: BarH like homeobox 1
Reporter: lacZ
Direct Detection
Results
Specimen 1D: embryonic day 16.5; Barhl1tm1Xia/Barhl1+ (more )
Structure Cell Type Level Pattern Image Note
TS24: organ of Corti cochlear inner hair cell Present Regionally restricted 1D Expression is in cochlear outer and inner hair cells, and saccular hair cells.
TS24: organ of Corti cochlear outer hair cell Present Regionally restricted 1D Expression is in cochlear outer and inner hair cells, and saccular hair cells.
TS24: inner ear vestibular component vestibular hair cell Present Regionally restricted 1D Expression is in hair cells.

Specimen 1E: embryonic day 16.5; Barhl1tm1Xia/Barhl1+ (more )
Structure Cell Type Level Pattern Image Note
TS24: organ of Corti cochlea auditory hair cell Present 1E Expression is in cochlear outer and inner hair cells, and saccular hair cells.
TS24: inner ear vestibular component vestibular hair cell Present 1E Expression is in hair cells.

Specimen 1F: postnatal day 5; Barhl1tm1Xia/Barhl1+ (more )
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear outer hair cell Strong Regionally restricted 1F Expression is strong in outer and weaker in inner hair cells and saccular hair cells.
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 1F Expression is strong in outer and weaker in inner hair cells and saccular hair cells.
TS28: inner ear vestibular component vestibular hair cell Present Regionally restricted 1F Expression is in hair cells.

Specimen 1G: postnatal day 5; Barhl1tm1Xia/Barhl1+ (more )
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear outer hair cell Strong Regionally restricted 1G Expression is strong in outer and weaker in inner hair cells and saccular hair cells.
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 1G Expression is strong in outer and weaker in inner hair cells and saccular hair cells.
TS28: inner ear vestibular component vestibular hair cell Present Regionally restricted 1G Expression is in hair cells.

Specimen 3E: postnatal day 6; Barhl1tm1Xia/Barhl1+ (more )
Note: Apical turn.
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 3E Expression is in hair cells.
TS28: organ of Corti cochlear outer hair cell Present Regionally restricted 3E Expression is in hair cells.

Specimen 3F: postnatal day 6; Barhl1tm1Xia/Barhl1tm1Xia (more )
Note: Apical turn.
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear outer hair cell Present Regionally restricted 3F Expression in this mutant illustrates that the outer hair cells in the apical turn of the organ of Corti show misalignment and disorganization.
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 3F

Specimen 3G: postnatal day 19; Barhl1tm1Xia/Barhl1tm1Xia (more )
Note: Apical turn.
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 3G Expression is in hair cells.
TS28: organ of Corti cochlear outer hair cell Present Regionally restricted 3G Expression is in hair cells.

Specimen 3H: postnatal day 59; Barhl1tm1Xia/Barhl1tm1Xia (more )
Note: Apical turn.
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 3H
TS28: organ of Corti cochlear outer hair cell Present Regionally restricted 3H

Specimen 3I: postnatal day 6; Barhl1tm1Xia/Barhl1+ (more )
Note: Middle turn.
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 3I
TS28: organ of Corti cochlear outer hair cell Present Regionally restricted 3I

Specimen 3J: postnatal day 6; Barhl1tm1Xia/Barhl1tm1Xia (more )
Note: Middle turn.
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 3J Expression in this mutant is similar to controls.
TS28: organ of Corti cochlear outer hair cell Present Regionally restricted 3J Expression in this mutant is similar to controls.

Specimen 3K: postnatal day 19; Barhl1tm1Xia/Barhl1tm1Xia (more )
Note: Middle turn.
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear outer hair cell Present Regionally restricted 3K Expression in this mutant illustrates that there is apical-to-basal progression of outer hair cell degeneration.
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 3K

Specimen 3L: postnatal day 59; Barhl1tm1Xia/Barhl1tm1Xia (more )
Note: Middle turn.
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear outer hair cell Present Regionally restricted 3L Expression in this mutant illustrates that there is apical-to-basal progression of outer hair cell degeneration.
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 3L

Specimen 3M: postnatal day 6; Barhl1tm1Xia/Barhl1+ (more )
Note: Basal turn.
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 3M
TS28: organ of Corti cochlear outer hair cell Present Regionally restricted 3M

Specimen 3N: postnatal day 6; Barhl1tm1Xia/Barhl1tm1Xia (more )
Note: Basal turn.
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 3N Expression in this mutant is similar to controls.
TS28: organ of Corti cochlear outer hair cell Present Regionally restricted 3N Expression in this mutant is similar to controls.

Specimen 3O: postnatal day 19; Barhl1tm1Xia/Barhl1tm1Xia (more )
Note: Basal turn.
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear outer hair cell Present Regionally restricted 3O Expression in this mutant illustrates that there is apical-to-basal progression of outer hair cell degeneration.
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 3O

Specimen 3P: postnatal day 59; Barhl1tm1Xia/Barhl1tm1Xia (more )
Note: Basal turn.
Structure Cell Type Level Pattern Image Note
TS28: organ of Corti cochlear outer hair cell Present Regionally restricted 3P Expression in this mutant illustrates that there is apical-to-basal progression of outer hair cell degeneration.
TS28: organ of Corti cochlear inner hair cell Present Regionally restricted 3P


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory