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Gene Expression Data
Assay Details
Assay
Reference: J:297164 Nie X, et al., mTOR plays a pivotal role in multiple processes of enamel organ development principally through the mTORC1 pathway and in part via regulating cytoskeleton dynamics. Dev Biol. 2020 Nov 1;467(1-2):77-87
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7467233
Gene symbol: Smad9
Gene name: SMAD family member 9
Antibody: Anti-phospho Smad1/Smad5/Smad8 (Ser463/465) AB3848-I
Detection system: Secondary antibody coupled to Alexa Fluor 546
Assay notes: The antibody used recognizes the phosphorylated form of the protein. The specificity of the antibody used was not detailed; all family members have been annotated.
Results
Specimen 3A: embryonic day 15.0; Mtortm1.2Koz/Mtor+ (more )
Structure Cell Type Level Pattern Image Note
TS23: lower jaw molar enamel organ preameloblast Present 3A
Specimen 3B: embryonic day 15.0; Mtortm1.2Koz/Mtortm1.2Koz, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS23: lower jaw molar enamel organ preameloblast Present 3B Reduced expression compared to controls.
Specimen 3C: embryonic day 16.5; Mtortm1.2Koz/Mtor+ (more )
Structure Level Pattern Image Note
TS24: lower jaw molar enamel organ Present 3C
Specimen 3D: embryonic day 16.5; Mtortm1.2Koz/Mtortm1.2Koz, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: lower jaw molar enamel organ Present 3D Reduced expression compared to controls.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/14/2024
MGI 6.23 		The Jackson Laboratory