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Gene Expression Data
Assay Details
Assay
Reference: J:297164 Nie X, et al., mTOR plays a pivotal role in multiple processes of enamel organ development principally through the mTORC1 pathway and in part via regulating cytoskeleton dynamics. Dev Biol. 2020 Nov 1;467(1-2):77-87
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7467224
Gene symbol: Rps6kb1
Gene name: ribosomal protein S6 kinase, polypeptide 1
Antibody: Anti-phospho-p70 S6 Kinase (Thr389), clone 10G7.1 (MABS82)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 6D: postnatal day 0; Mtortm1.2Koz/Mtor+ (more )
Structure Cell Type Level Pattern Image Note
TS27: lower jaw molar enamel organ ameloblast Present 6D
TS27: lower jaw molar mesenchyme odontoblast Present 6D
Specimen 6E: postnatal day 0; Mtortm1.2Koz/Mtortm1.2Koz, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: lower jaw molar enamel organ ameloblast Present 6E Reduced expression compared to controls.
TS27: lower jaw molar mesenchyme odontoblast Present 6E Reduced expression compared to controls.
Specimen 6F: postnatal day 0; Tg(KRT14-cre)1Amc/0, Tsc1tm1Djk/Tsc1tm1Djk (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: lower jaw molar enamel organ ameloblast Strong 6F Increased expression compared to controls.
TS27: lower jaw molar mesenchyme odontoblast Strong 6F Increased expression compared to controls.
Specimen S3D: postnatal day 0; Mtortm1.2Koz/Mtor+ (more )
Structure Cell Type Level Pattern Image Note
TS27: lower jaw molar enamel organ ameloblast Present S3D
TS27: lower jaw molar mesenchyme odontoblast Present S3D
Specimen S3E: postnatal day 0; Mtortm1.2Koz/Mtortm1.2Koz, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: lower jaw molar enamel organ ameloblast Present S3E Reduced expression compared to controls.
TS27: lower jaw molar mesenchyme odontoblast Present S3E Reduced expression compared to controls.
Specimen S3F: postnatal day 0; Tg(KRT14-cre)1Amc/0, Tsc1tm1Djk/Tsc1tm1Djk (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: lower jaw molar enamel organ ameloblast Strong S3F Increased expression compared to controls.
TS27: lower jaw molar mesenchyme odontoblast Strong S3F Increased expression compared to controls.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/07/2024
MGI 6.23 		The Jackson Laboratory