Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Npr3em1(cre/ERT2)Bz
Name:	natriuretic peptide receptor 3; endonuclease-mediated mutation 1, Bin Zhou
MGI ID:	MGI:7467076
Synonyms:	Npr3CreERT2
Gene:	Npr3  Location: Chr15:11839982-11907287 bp, - strand  Genetic Position: Chr15, 5.83 cM
Alliance:	Npr3em1(cre/ERT2)Bz page

Germline Transmission:	Earliest citation of germline transmission: J:317975
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Endonuclease-mediated (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Npr3em1(cre/ERT2)Bz expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Npr3 (MGI:97373)   Mutation details: The allele was generated by knocking in a 2A peptide-linked creERT2 cDNA immediately before the stop codon of the Npr3 by CRISPRCas9 targeting and homozygous recombination in R1 mouse embryonic stem cells. (J:317975)

Activity:	Tissue activity of this recombinase allele
Driver:	Npr3 (mouse) Summary of all recombinase alleles driven by Npr3. Comparative matrix view of recombinase activities Alliance mouse Npr3 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npr3 Mutation:	47 strains or lines available

Original:	J:317975 Lu P, et al., Perinatal angiogenesis from pre-existing coronary vessels via DLL4-NOTCH1 signalling. Nat Cell Biol. 2021 Sep;23(9):967-977
All:	2 reference(s)