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Gene Expression Data
Assay Details
Assay
Reference: J:297164 Nie X, et al., mTOR plays a pivotal role in multiple processes of enamel organ development principally through the mTORC1 pathway and in part via regulating cytoskeleton dynamics. Dev Biol. 2020 Nov 1;467(1-2):77-87
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7467026
Gene symbol: Sox2
Gene name: SRY (sex determining region Y)-box 2
Antibody: anti-Sox2
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 2N: embryonic day 15.5; Mtortm1.2Koz/Mtor+ (more )
Structure Cell Type Level Pattern Image Note
TS23: outer enamel epithelium Present Regionally restricted 2N Expressed at the lingual sides.
TS23: inner enamel epithelium preameloblast Absent 2N
Specimen 2O: embryonic day 15.5; Mtortm1.2Koz/Mtortm1.2Koz, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS23: outer enamel epithelium Present 2O
TS23: inner enamel epithelium preameloblast Present 2O Aberrant expression was seen.
Specimen 2P: embryonic day 16.5; Mtortm1.2Koz/Mtor+ (more )
Structure Cell Type Level Pattern Image Note
TS24: outer enamel epithelium Present Regionally restricted 2P Expressed at the lingual sides.
TS24: inner enamel epithelium preameloblast Absent 2P
Specimen 2Q: embryonic day 16.5; Mtortm1.2Koz/Mtortm1.2Koz, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS24: outer enamel epithelium Present 2Q
TS24: inner enamel epithelium preameloblast Present 2Q Aberrant expression was seen.
Specimen 2X: postnatal day 0; Mtortm1.2Koz/Mtor+ (more )
Structure Level Pattern Image Note
TS27: cervical loop Present 2X
Specimen 2Y: postnatal day 0; Mtortm1.2Koz/Mtortm1.2Koz, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: cervical loop Present 2Y Reduced number of positive cells compared with the control.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/28/2024
MGI 6.13 		The Jackson Laboratory