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Gene Expression Data
Assay Details
Assay
Reference: J:297164 Nie X, et al., mTOR plays a pivotal role in multiple processes of enamel organ development principally through the mTORC1 pathway and in part via regulating cytoskeleton dynamics. Dev Biol. 2020 Nov 1;467(1-2):77-87
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7467023
Gene symbol: Mtor
Gene name: mechanistic target of rapamycin kinase
Antibody: anti-Ser2448p-mTOR (EPR426(2), ab109268)
Detection system: Secondary antibody coupled to Alexa Fluor 546
Results
Specimen 1A: embryonic day 13.5; Mtortm1.2Koz/Mtor+ (more )
Structure Level Pattern Image Note
TS21: lower jaw molar epithelium Strong Ubiquitous 1A
TS21: lower jaw molar mesenchyme Strong Ubiquitous 1A
Specimen 1B: embryonic day 15.0; Mtortm1.2Koz/Mtor+ (more )
Structure Level Pattern Image Note
TS23: lower jaw molar enamel organ Strong Widespread 1B Expressed in all cell layers.
TS23: lower jaw molar mesenchyme Present 1B Expressed at a relatively a low level.
TS23: inner enamel epithelium Strong 1B
TS23: outer enamel epithelium Strong 1B
TS23: stellate reticulum Strong 1B
Specimen 1C: embryonic day 15.0; Mtortm1.2Koz/Mtortm1.2Koz, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS23: lower jaw molar enamel organ Trace 1C Dramatically reduced expression compared to controls.
Specimen 1E: postnatal day 0; Mtortm1.2Koz/Mtor+ (more )
Structure Cell Type Level Pattern Image Note
TS27: lower jaw molar enamel organ ameloblast Strong 1E
TS27: lower jaw molar mesenchyme odontoblast Strong 1E
Specimen 1F: postnatal day 0; Mtortm1.2Koz/Mtor+ (more )
Structure Cell Type Level Pattern Image Note
TS27: incisor enamel organ ameloblast Strong 1F
TS27: incisor mesenchyme odontoblast Strong 1F
Specimen 6A: postnatal day 0; Mtortm1.2Koz/Mtor+ (more )
Structure Cell Type Level Pattern Image Note
TS27: lower jaw molar enamel organ ameloblast Present 6A
Specimen 6B: postnatal day 0; Mtortm1.2Koz/Mtortm1.2Koz, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: lower jaw molar enamel organ ameloblast Present 6B Reduced expression compared to controls.
Specimen 6C: postnatal day 0; Tg(KRT14-cre)1Amc/0, Tsc1tm1Djk/Tsc1tm1Djk (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: lower jaw molar enamel organ ameloblast Strong 6C Increased expression compared to controls.
Specimen S3A: postnatal day 0; Mtortm1.2Koz/Mtor+ (more )
Structure Cell Type Level Pattern Image Note
TS27: lower jaw molar enamel organ ameloblast Present S3A
Specimen S3B: postnatal day 0; Mtortm1.2Koz/Mtortm1.2Koz, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: lower jaw molar enamel organ ameloblast Present S3B Reduced expression compared to controls.
Specimen S3C: postnatal day 0; Tg(KRT14-cre)1Amc/0, Tsc1tm1Djk/Tsc1tm1Djk (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS27: lower jaw molar enamel organ ameloblast Strong S3C Increased expression compared to controls.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory