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Gene Expression Data
Assay Details
Assay
Reference: J:173287 Long JE, et al., Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways. J Comp Neurol. 2009 Feb 1;512(4):556-72
Assay type: RNA in situ
MGI Accession ID: MGI:7464420
Gene symbol: Dlx1
Gene name: distal-less homeobox 1
Probe: Dlx1 cDNA
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Assay notes: The probe recognized the truncated transcript in the mutant. Table 4 data was incorporated into Fig. 7 &S2 samples, as per the text.
Results
Specimen 1a: embryonic day 15.5 (more )
Note: littermate control; the genetic background of the specimen is either +/+ or +/-
Structure Level Pattern Image Note
TS23: lateral ganglionic eminence Present Graded 1a Expressed in a dorsoventral grandient in progenitor cells of the lateral ganglionic eminence. Expression was particularly high in the dorsal LGE, where it was detected in most cells in both the ventricular and subventricular zones.
TS23: lateral ganglionic eminence mantle zone Present Graded 1a Expressed in a dorsoventral grandient in progenitor cells of the lateral ganglionic eminence. Expression was particularly high in the dorsal LGE, where it was detected in most cells in both the ventricular and subventricular zones.
TS23: lateral ganglionic eminence ventricular zone Present Graded 1a Expressed in a dorsoventral grandient in progenitor cells of the lateral ganglionic eminence. Expression was particularly high in the dorsal LGE, where it was detected in most cells in both the ventricular and subventricular zones.
TS23: telencephalon septum Present Graded 1a Expressed in a dorsoventral grandient.
Specimen 1a': embryonic day 15.5; Del(2Dlx1-Dlx2)1Jlr/Del(2Dlx1-Dlx2)1Jlr (more )
Structure Level Pattern Image Note
TS23: lateral ganglionic eminence subventricular zone Weak Regionally restricted 1a' Expression continued at low levels through the subventricular zone.
TS23: lateral ganglionic eminence mantle zone Absent 1a'
Specimen 7e: embryonic day 15.5 (more )
Note: littermate control; the genetic background of the specimen is either +/+ or +/-
Structure Level Pattern Image Note
TS23: telencephalon septum Present 7e , S2a
TS23: lateral ganglionic eminence mantle zone Present S2a , 7e
TS23: lateral ganglionic eminence subventricular zone Present S2a , 7e
TS23: lateral ganglionic eminence ventricular zone Present S2a , 7e
Specimen 7e': embryonic day 15.5; Del(2Dlx1-Dlx2)1Jlr/Del(2Dlx1-Dlx2)1Jlr (more )
Structure Level Pattern Image Note
TS23: telencephalon septum Weak Regionally restricted S2a' , 7e' Expression was moderately/mildly decreased in the subventricular zone. Expression was severely decreased in the mantle zone. It was undetectable in the ventricular zone.
TS23: lateral ganglionic eminence subventricular zone Present Regionally restricted 7e' , S2a' Expression was moderately/mildly decreased.
TS23: lateral ganglionic eminence ventricular zone Present Regionally restricted 7e' , S2a' Expression was moderately/mildly decreased.
TS23: lateral ganglionic eminence mantle zone Absent S2a' , 7e'
Specimen 7e'': embryonic day 15.5; Ascl1tm1And/Ascl1tm1And (more )
Structure Level Pattern Image Note
TS23: telencephalon septum Present Regionally restricted S2a'' , 7e'' Expression was increased in the subventricular zone. Expression was unchanged in the mantle zone. It was undetectable in the ventricular zone.
TS23: lateral ganglionic eminence subventricular zone Strong S2a'' , 7e'' Expression was increased.
TS23: lateral ganglionic eminence ventricular zone Strong S2a'' , 7e'' Expression was increased.
TS23: lateral ganglionic eminence mantle zone Present 7e'' , S2a'' Expression was unchanged.
Specimen 7e''': embryonic day 15.5; Ascl1tm1And/Ascl1tm1And, Del(2Dlx1-Dlx2)1Jlr/Del(2Dlx1-Dlx2)1Jlr (more )
Structure Level Pattern Image Note
TS23: telencephalon septum Weak Regionally restricted 7e''' Expression was severely decreased in the subventricular zone and mantle zone. Expression was unchanged in the ventricular zone.
TS23: lateral ganglionic eminence mantle zone Weak 7e''' Expression was severely decreased.
TS23: lateral ganglionic eminence subventricular zone Weak 7e''' Expression was severely decreased.
TS23: lateral ganglionic eminence ventricular zone Present 7e''' Expression was unchanged.
Specimen S1a: embryonic day 12.5 (more )
Note: littermate control; the genetic background of the specimen is either +/+ or +/-
Structure Level Pattern Image Note
TS20: lateral ganglionic eminence Present Graded S1a Expressed in a dorsoventral grandient in progenitor cells of the lateral ganglionic eminence.
Specimen S1a': embryonic day 12.5; Del(2Dlx1-Dlx2)1Jlr/Del(2Dlx1-Dlx2)1Jlr (more )
Structure Level Pattern Image Note
TS20: lateral ganglionic eminence subventricular zone Weak S1a'
TS20: lateral ganglionic eminence mantle zone Absent S1a'
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
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