Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Per1-Kcnma1*R207Q)#Alme
Name:	transgene insertion, Andrea L Meredith
MGI ID:	MGI:7464147
Synonyms:	Tg-BKR207Q
Transgene:	Tg(Per1-Kcnma1*R207Q)#Alme  Location: unknown
Alliance:	Tg(Per1-Kcnma1*R207Q)#Alme page

Strain of Origin:

Not Applicable

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Per1-Kcnma1*R207Q)#Alme expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Kcnma1 (MGI:99923) expresses mouse cDNA with R207Q mutation, driven by mouse promoter   Mutation details: The transgene contains the following elements: a 6,756 bp DNA fragment containing the putative Per1 promoter sequence and the 5'-untranslated region, which encompasses exon 1 and part of exon 2, a modified Kcnma1 cDNA where arginine codon 207 was changed to glutamine (p.R207Q), and hemoglobin beta poly(A) signal sequences. This is a fast-activating gain-of-function mutation. (J:191740)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:191740 Montgomery JR, et al., Genetic activation of BK currents in vivo generates bidirectional effects on neuronal excitability. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18997-9002
All:	1 reference(s)