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Gene Expression Data
Assay Details
Assay
Reference: J:203791 Kuracha MR, et al., Spry1 and Spry2 are necessary for eyelid closure. Dev Biol. 2013 Nov 15;383(2):227-38
Assay type: RNA in situ
MGI Accession ID: MGI:7464152
Gene symbol: Spry4
Gene name: sprouty RTK signaling antagonist 4
Probe: Spry4 probe
Probe preparation: Antisense labelled with S35 RNA
Visualized with: Autoradiography
Results
Specimen 1C: embryonic day 12.5 (more )
Structure Cell Type Level Pattern Image Note
TS20: eye epithelium conjunctival epithelial cell Absent 1C
TS20: eye mesenchyme Present Regionally restricted 1C Expressed in mesenchymal cells adjacent to the conjunctival epithelia.
Specimen 1F: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: eyelid mesenchyme Present 1F Expression was broader.
Specimen 1I/I': embryonic day 15.5 (more )
Structure Cell Type Level Pattern Image Note
TS23: eyelid epidermal cell Present Regionally restricted 1I Expressed in the palpebral epidermal cells.
TS23: eyelid mesenchyme Present 1I , 1I' Expression was broader.
TS23: periderm peridermal cell Present Regionally restricted 1I' Expressed in peridermal cells at the leading edge of the eyelid.
Specimen 1M: embryonic day 14.5; Spry1tm1Jdli/Spry1tm1Jdli, Spry2tm1Mrt/Spry2tm1Mrt, Tg(Pax6-cre,GFP)1Pgr/0 (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS22: eyelid mesenchyme Present Regionally restricted 1M Increased expression in the mesenchymal cells adjacent to the bulbar and palpebral conjunctival epithelia compared with the control.
TS22: conjunctival sac Present Regionally restricted 1M Increased expression in the bulbar mesenchymal cells compared with the control.
TS22: conjunctiva epithelium conjunctival epithelial cell Present Regionally restricted 1M Modestly increased expression in the palpebral conjunctival epithelial cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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