Tg(Rr418-Luc)Harry1Ward
Transgene Detail
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| Symbol: |
Tg(Rr418-Luc)Harry1Ward |
| Name: |
transgene insertion Harry1, Andrew Ward |
| MGI ID: |
MGI:7461629 |
| Synonyms: |
Harry, Rr505561Tg(Rr418-Luc)Harry1Ward, Sox10Hry, Sox10Tg(Igf2P3Luc)HarryWard |
| Transgene: |
Tg(Rr418-Luc)Harry1Ward Location: unknown Genetic Position: Chr15, Syntenic
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| Alliance: |
Tg(Rr418-Luc)Harry1Ward page
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| Strain of Origin: |
Not Applicable
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| Transgene Type: |
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Transgenic (Modified regulatory region, Reporter) |
| Mutation: |
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Insertion
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Mutation details: The transgene contains the following elements: Igf2 promoter 3 (Rr146; from 162 bp upstream of TSS of exon 3/alternative exon 1 [chr7:142211218 GRCm39] to 74 bp of 5' UTR in exon 3), an Igf2 enhancer (Rr418) from between H19 and Igf2, the luciferase reporter gene and SV40 poly(A) signal sequences. A number of independent lines were generated; this allele replaced ~15.9 kb sequence upstream of Sox10 that contains an enhancer (Rr505561), leading to disruption of its expression when homozygous. The Igf2 enhancer drives expression of the reporter in the brain.
(J:334634)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:334634 Ward A, et al., Genomic regions regulating imprinting and insulin-like growth factor-II promoter 3 activity in transgenics: novel enhancer and silencer elements. Genes Funct. 1997 Feb;1(1):25-36 |
| All: |
2 reference(s) |
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Analysis Tools
