Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Cochem1(cre)Bcgen
Name:	cochlin; endonuclease-mediated mutation 1, Biocytogen LLC
MGI ID:	MGI:7461129
Synonyms:	COCH-CRE
Gene:	Coch  Location: Chr12:51640156-51652558 bp, + strand  Genetic Position: Chr12, 22.11 cM
Alliance:	Cochem1(cre)Bcgen page

Strain of Origin:

Not Specified

Allele Type:    Endonuclease-mediated (Recombinase) Mutation:    Insertion   Cochem1(cre)Bcgen expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Coch (MGI:1278313)   Mutation details: CRE (cyclization recombination enzyme) was knocked in between the Coch Exon 11 and the 3'-untranslated region resulting in protein CRE being appended to the C-terminus of the Coch gene separated by a 2A peptide. (J:328337)

Activity:	Tissue activity of this recombinase allele
Driver:	Coch (mouse) Summary of all recombinase alleles driven by Coch. Comparative matrix view of recombinase activities Alliance mouse Coch gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Coch Mutation:	42 strains or lines available

Original:	J:328337 Jing W, et al., A circuit of COCH neurons encodes social-stress-induced anxiety via MTF1 activation of Cacna1h. Cell Rep. 2021 Dec 28;37(13):110177
All:	1 reference(s)