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Gene Expression Data
Assay Details
Assay
Reference: J:278094 Pu W, et al., Genetic Targeting of Organ-Specific Blood Vessels. Circ Res. 2018 Jun 22;123(1):86-99
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7460310
Gene symbol: Kdr
Gene name: kinase insert domain protein receptor
Antibody: anti-Flk-1 (Clone Avas 12alpha1)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 3B - Control: embryonic day 14.5; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Kdrtm1Wag/Kdr+, Tekem1(dre)Bzsh/Tek+, Wt1em1(cre/ERT2)Bzsh/Wt1+ (more )
Note: Conditional mutant. Triple labeled: green - Kdr; gray - Cdh5 (assay MGI:7451396); red - recombinase reporter.
Structure Cell Type Level Pattern Image Note
TS22: compact myocardium cardiac endothelial cell Present 3B Merge Control , 3B VEGFR2 Control
TS22: trabecular myocardium endocardial cell Present 3B VEGFR2 Control , 3B Merge Control
Specimen 3B - Mutant: embryonic day 14.5; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Kdrtm1Wag/Kdrtm1Wag, Tekem1(dre)Bzsh/Tek+, Wt1em1(cre/ERT2)Bzsh/Wt1+ (more )
Note: Conditional mutant. Triple labeled: green - Kdr; gray - Cdh5 (assay MGI:7451396); red - recombinase reporter.
Structure Cell Type Level Pattern Image Note
TS22: compact myocardium cardiac endothelial cell Trace 3B VEGFR2 Mutant , 3B Merge Mutant The number of coronary endothelial cells is reduced to 11.8% in the mutant.
TS22: trabecular myocardium endocardial cell Present 3B VEGFR2 Mutant , 3B Merge Mutant The number of endothelial cells is unaffected in the mutant.
Specimen Online VIA: embryonic day 14.5; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Kdrtm1Wag/Kdr+, Tekem1(dre)Bzsh/Tek+, Wt1em1(cre/ERT2)Bzsh/Wt1+ (more )
Note: Conditional mutant. Triple labeled: green - Kdr; blue - Mki67 (assay MGI:7460323); red - recombinase reporter.
Structure Cell Type Level Pattern Image Note
TS22: compact myocardium cardiac endothelial cell Present Online VIA VEGFR2 , Online VIA Merge
Specimen Online VIB: embryonic day 14.5; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Kdrtm1Wag/Kdrtm1Wag, Tekem1(dre)Bzsh/Tek+, Wt1em1(cre/ERT2)Bzsh/Wt1+ (more )
Note: Conditional mutant. Double labeled: green - Kdr; blue - Mki67 (assay MGI:7460323).
Structure Cell Type Level Pattern Image Note
TS22: compact myocardium cardiac endothelial cell Present Online VIB VEGFR2 , Online VIB Merge The number of coronary endothelial cells is reduced to 11.8% in the mutant; the remaining cells display a higher degree of proliferation.
Specimen 5B - Control: postnatal day 0; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Kdrtm1Wag/Kdr+, Mfsd2aem2(cre/ERT2)Bzsh/Mfsd2a+, Tekem1(dre)Bzsh/Tek+ (more )
Note: Conditional mutant. Triple labeled: green - Kdr; gray - Cdh5 (assay MGI:7451396); red - recombinase reporter.
Structure Cell Type Level Pattern Image Note
TS27: brain blood vessel blood vessel endothelial cell Present 5B VEGFR2 Control , 5B Merge Control , 5B Magnification Control
Specimen 5B - Mutant: postnatal day 0; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Kdrtm1Wag/Kdrtm1Wag, Mfsd2aem2(cre/ERT2)Bzsh/Mfsd2a+, Tekem1(dre)Bzsh/Tek+ (more )
Note: Conditional mutant. Triple labeled: green - Kdr; gray - Cdh5 (assay MGI:7451396); red - recombinase reporter.
Structure Cell Type Level Pattern Image Note
TS27: brain blood vessel blood vessel endothelial cell Trace 5B VEGFR2 Mutant , 5B Merge Mutant , 5B Magnification Mutant The number of expressing vessels is reduced to 3% of that seen in the control.
Specimen Online XII - Control Brain: postnatal day 0; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Kdrtm1Wag/Kdr+, Mfsd2aem2(cre/ERT2)Bzsh/Mfsd2a+, Tekem1(dre)Bzsh/Tek+ (more )
Note: Conditional mutant. Double labeled: green - Kdr; red - recombinase reporter.
Structure Cell Type Level Pattern Image Note
TS27: brain blood vessel blood vessel endothelial cell Present Online XII_Brain Control
Specimen Online XII - Mutant Brain: postnatal day 0; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Kdrtm1Wag/Kdrtm1Wag, Mfsd2aem2(cre/ERT2)Bzsh/Mfsd2a+, Tekem1(dre)Bzsh/Tek+ (more )
Note: Conditional mutant. Double labeled: green - Kdr; red - recombinase reporter.
Structure Cell Type Level Pattern Image Note
TS27: brain blood vessel blood vessel endothelial cell Absent Online XII_Brain Mutant
Specimen Online XII - Control Heart: postnatal day 0; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Kdrtm1Wag/Kdr+, Mfsd2aem2(cre/ERT2)Bzsh/Mfsd2a+, Tekem1(dre)Bzsh/Tek+ (more )
Note: Conditional mutant. Double labeled: green - Kdr; red - recombinase reporter.
Structure Cell Type Level Pattern Image Note
TS27: heart blood vessel blood vessel endothelial cell Present Online XII_Heart Control
Specimen Online XII - Mutant Heart: postnatal day 0; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Kdrtm1Wag/Kdrtm1Wag, Mfsd2aem2(cre/ERT2)Bzsh/Mfsd2a+, Tekem1(dre)Bzsh/Tek+ (more )
Note: Conditional mutant. Double labeled: green - Kdr; red - recombinase reporter.
Structure Cell Type Level Pattern Image Note
TS27: heart blood vessel blood vessel endothelial cell Present Online XII_Heart Mutant Expression in the mutant is the same as in wild type.
Specimen Online XII - Control Lung: postnatal day 0; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Kdrtm1Wag/Kdr+, Mfsd2aem2(cre/ERT2)Bzsh/Mfsd2a+, Tekem1(dre)Bzsh/Tek+ (more )
Note: Conditional mutant. Double labeled: green - Kdr; red - recombinase reporter.
Structure Cell Type Level Pattern Image Note
TS27: lung vascular element blood vessel endothelial cell Present Online XII_Lung Control
Specimen Online XII - Mutant Lung: postnatal day 0; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Kdrtm1Wag/Kdrtm1Wag, Mfsd2aem2(cre/ERT2)Bzsh/Mfsd2a+, Tekem1(dre)Bzsh/Tek+ (more )
Note: Conditional mutant. Double labeled: green - Kdr; red - recombinase reporter.
Structure Cell Type Level Pattern Image Note
TS27: lung vascular element blood vessel endothelial cell Present Online XII_Lung Mutant Expression in the mutant is the same as in wild type.
Specimen Online XII - Control Muscle: postnatal day 0; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Kdrtm1Wag/Kdr+, Mfsd2aem2(cre/ERT2)Bzsh/Mfsd2a+, Tekem1(dre)Bzsh/Tek+ (more )
Note: Conditional mutant. Double labeled: green - Kdr; red - recombinase reporter.
Structure Cell Type Level Pattern Image Note
TS27: muscle blood vessel blood vessel endothelial cell Present Online XII_Muscle Control
Specimen Online XII - Mutant Muscle: postnatal day 0; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Kdrtm1Wag/Kdrtm1Wag, Mfsd2aem2(cre/ERT2)Bzsh/Mfsd2a+, Tekem1(dre)Bzsh/Tek+ (more )
Note: Conditional mutant. Double labeled: green - Kdr; red - recombinase reporter.
Structure Cell Type Level Pattern Image Note
TS27: muscle blood vessel blood vessel endothelial cell Present Online XII_Muscle Mutant Expression in the mutant is the same as in wild type.
Specimen Online XII - Control Stomach: postnatal day 0; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Kdrtm1Wag/Kdr+, Mfsd2aem2(cre/ERT2)Bzsh/Mfsd2a+, Tekem1(dre)Bzsh/Tek+ (more )
Note: Conditional mutant. Double labeled: green - Kdr; red - recombinase reporter.
Structure Cell Type Level Pattern Image Note
TS27: stomach vascular element blood vessel endothelial cell Present Online XII_Stomach Control
Specimen Online XII - Mutant Stomach: postnatal day 0; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Kdrtm1Wag/Kdrtm1Wag, Mfsd2aem2(cre/ERT2)Bzsh/Mfsd2a+, Tekem1(dre)Bzsh/Tek+ (more )
Note: Conditional mutant. Double labeled: green - Kdr; red - recombinase reporter.
Structure Cell Type Level Pattern Image Note
TS27: stomach vascular element blood vessel endothelial cell Present Online XII_Stomach Mutant Expression in the mutant is the same as in wild type.
Specimen Online XII - Control Intestine: postnatal day 0; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Kdrtm1Wag/Kdr+, Mfsd2aem2(cre/ERT2)Bzsh/Mfsd2a+, Tekem1(dre)Bzsh/Tek+ (more )
Note: Conditional mutant. Double labeled: green - Kdr; red - recombinase reporter.
Structure Cell Type Level Pattern Image Note
TS27: intestine vascular element blood vessel endothelial cell Present Online XII_Intestine Control
Specimen Online XII - Mutant Intestine: postnatal day 0; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Kdrtm1Wag/Kdrtm1Wag, Mfsd2aem2(cre/ERT2)Bzsh/Mfsd2a+, Tekem1(dre)Bzsh/Tek+ (more )
Note: Conditional mutant. Double labeled: green - Kdr; red - recombinase reporter.
Structure Cell Type Level Pattern Image Note
TS27: intestine vascular element blood vessel endothelial cell Present Online XII_Intestine Mutant Expression in the mutant is the same as in wild type.
Specimen Online XII - Control Liver: postnatal day 0; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Kdrtm1Wag/Kdr+, Mfsd2aem2(cre/ERT2)Bzsh/Mfsd2a+, Tekem1(dre)Bzsh/Tek+ (more )
Note: Conditional mutant. Double labeled: green - Kdr; red - recombinase reporter.
Structure Cell Type Level Pattern Image Note
TS27: liver vasculature blood vessel endothelial cell Present Online XII_Liver Control
Specimen Online XII - Mutant Liver: postnatal day 0; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Kdrtm1Wag/Kdrtm1Wag, Mfsd2aem2(cre/ERT2)Bzsh/Mfsd2a+, Tekem1(dre)Bzsh/Tek+ (more )
Note: Conditional mutant. Double labeled: green - Kdr; red - recombinase reporter.
Structure Cell Type Level Pattern Image Note
TS27: liver vasculature blood vessel endothelial cell Present Online XII_Liver Mutant Expression in the mutant is the same as in wild type.
Specimen Online XII - Control Kidney: postnatal day 0; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Kdrtm1Wag/Kdr+, Mfsd2aem2(cre/ERT2)Bzsh/Mfsd2a+, Tekem1(dre)Bzsh/Tek+ (more )
Note: Conditional mutant. Double labeled: green - Kdr; red - recombinase reporter.
Structure Cell Type Level Pattern Image Note
TS27: renal vasculature blood vessel endothelial cell Present Online XII_Kidney Control
Specimen Online XII - Mutant Kidney: postnatal day 0; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Kdrtm1Wag/Kdrtm1Wag, Mfsd2aem2(cre/ERT2)Bzsh/Mfsd2a+, Tekem1(dre)Bzsh/Tek+ (more )
Note: Conditional mutant. Double labeled: green - Kdr; red - recombinase reporter.
Structure Cell Type Level Pattern Image Note
TS27: renal vasculature blood vessel endothelial cell Present Online XII_Kidney Mutant Expression in the mutant is the same as in wild type.
Specimen Online XII - Control Pancreas: postnatal day 0; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Kdrtm1Wag/Kdr+, Mfsd2aem2(cre/ERT2)Bzsh/Mfsd2a+, Tekem1(dre)Bzsh/Tek+ (more )
Note: Conditional mutant. Double labeled: green - Kdr; red - recombinase reporter.
Structure Cell Type Level Pattern Image Note
TS27: pancreas vasculature blood vessel endothelial cell Present Online XII_Pancreas Control
Specimen Online XII - Mutant Pancreas: postnatal day 0; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Kdrtm1Wag/Kdrtm1Wag, Mfsd2aem2(cre/ERT2)Bzsh/Mfsd2a+, Tekem1(dre)Bzsh/Tek+ (more )
Note: Conditional mutant. Double labeled: green - Kdr; red - recombinase reporter.
Structure Cell Type Level Pattern Image Note
TS27: pancreas vasculature blood vessel endothelial cell Present Online XII_Pancreas Mutant Expression in the mutant is the same as in wild type.
Specimen Online XII - Control Skin: postnatal day 0; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Kdrtm1Wag/Kdr+, Mfsd2aem2(cre/ERT2)Bzsh/Mfsd2a+, Tekem1(dre)Bzsh/Tek+ (more )
Note: Conditional mutant. Double labeled: green - Kdr; red - recombinase reporter.
Structure Cell Type Level Pattern Image Note
TS27: skin blood vessel blood vessel endothelial cell Present Online XII_Skin Control
Specimen Online XII - Mutant Skin: postnatal day 0; Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+, Kdrtm1Wag/Kdrtm1Wag, Mfsd2aem2(cre/ERT2)Bzsh/Mfsd2a+, Tekem1(dre)Bzsh/Tek+ (more )
Note: Conditional mutant. Double labeled: green - Kdr; red - recombinase reporter.
Structure Cell Type Level Pattern Image Note
TS27: skin blood vessel blood vessel endothelial cell Present Online XII_Skin Mutant Expression in the mutant is the same as in wild type.
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