Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Ccna2em1(cre/ERT2)Bzsh
Name:	cyclin A2; endonuclease-mediated mutation 1, Bin Zhou
MGI ID:	MGI:7451131
Synonyms:	Ccna2-CrexER
Gene:	Ccna2  Location: Chr3:36619014-36626299 bp, - strand  Genetic Position: Chr3, 17.67 cM
Alliance:	Ccna2em1(cre/ERT2)Bzsh page

Strain of Origin:

Not Specified

Allele Type:    Endonuclease-mediated (Conditional ready, Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Ccna2em1(cre/ERT2)Bzsh expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Ccna2 (MGI:108069)   Mutation details: Using CRISPR/Cas9 technology, the CrexER (Cre-rox-ER-rox) was generated by the insertion of two rox sequences flanking ERT2, a cDNA encoding CrexER recombinase was inserted into the translational stop codon of the Ccna2 gene, following endogenous Ccna2 by the self-cleaving peptide 2A sequence. (J:303771, J:339117)

Activity:	Tissue activity of this recombinase allele
Driver:	Ccna2 (mouse) Summary of all recombinase alleles driven by Ccna2. Alliance mouse Ccna2 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccna2 Mutation:	15 strains or lines available

Original:	J:303771 He L, et al., Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair. Science. 2021 Feb 26;371(6532)
All:	2 reference(s)