Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Mki67em1(cre/ERT2)Bzsh
Name:	antigen identified by monoclonal antibody Ki 67; endonuclease-mediated mutation 1, Bin Zhou
MGI ID:	MGI:7451128
Synonyms:	Ki67-CrexER
Gene:	Mki67  Location: Chr7:135291513-135318090 bp, - strand  Genetic Position: Chr7, 81.32 cM, cytoband F3-F5
Alliance:	Mki67em1(cre/ERT2)Bzsh page

Strain of Origin:

Not Specified

Allele Type:    Endonuclease-mediated (Conditional ready, Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Mki67em1(cre/ERT2)Bzsh expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Mki67 (MGI:106035)   Mutation details: Using CRISPR/Cas9 technolgy, the CrexER (Cre-rox-ER-rox) was generated by the insertion of two rox sequences flanking ERT2, a cDNA encoding CrexER recombinase replaced the translational stop codon of the Mki67 gene, following endogenous Mki67 by the self-cleaving peptide 2A sequence. (J:303771, J:339117)

Activity:	Tissue activity of this recombinase allele
Driver:	Mki67 (mouse) Summary of all recombinase alleles driven by Mki67. Alliance mouse Mki67 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mki67 Mutation:	147 strains or lines available

Original:	J:303771 He L, et al., Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair. Science. 2021 Feb 26;371(6532)
All:	2 reference(s)