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Gene Expression Data
Assay Details
Assay
Reference: J:324296 Bell N, et al., Overexpression of transcription factor FoxA2 in the developing skeleton causes an enlargement of the cartilage hypertrophic zone, but it does not trigger ectopic differentiation in immature chondrocytes. Bone. 2022 Apr 6;160:116418
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7450978
Gene symbol: Foxa2
Gene name: forkhead box A2
Antibody: anti-HNF3beta/FOXA2 (07-633)
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to horseradish peroxidase
Results
Specimen 1a2: embryonic day 12.0 (more )
Structure Level Pattern Image Note
TS20: limb pre-cartilage condensation Absent 1a2 No expression in chondrogenic condensations.
Specimen 1b2: embryonic day 15.0 (more )
Structure Level Pattern Image Note
TS23: limb cartilage condensation Strong Regionally restricted 1b2 Highly expressed in hypertrophic zone. Domain of expression in resting zone in periarticular region of growth plate.
Specimen 1c2: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: limb long bone Strong Regionally restricted 1c2 Highly expressed in hypertrophic zone. Domain of expression in resting zone in periarticular region of growth plate.
Specimen 1c2.1: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: long bone metaphysis Absent 1c2.1 No expression in metaphyseal bone.
Specimen 1c2.2: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: epiphyseal plate hypertrophic zone Strong 1c2.2
Specimen 1c2.3: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: epiphyseal plate proliferative zone Absent 1c2.3
Specimen 1c2.4: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: epiphyseal plate resting zone Present Regionally restricted 1c2.4 Domain of expression in resting zone in periarticular region of growth plate.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory