Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Find Mice (IMSR) | References

Symbol:	P2ry12em1(cre/ERT2)Peng
Name:	purinergic receptor P2Y, G-protein coupled 12; endonuclease-mediated mutation 1, Bo Peng
MGI ID:	MGI:7450934
Synonyms:	P2Y12-CreER-GFP
Gene:	P2ry12  Location: Chr3:59123693-59170292 bp, - strand  Genetic Position: Chr3, 29.01 cM
Alliance:	P2ry12em1(cre/ERT2)Peng page

Strain of Origin:

Not Specified

Allele Type:    Endonuclease-mediated (Inducible, Recombinase, Reporter) Inducer:    tamoxifen Mutation:    Insertion   P2ry12em1(cre/ERT2)Peng expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse P2ry12 (MGI:1918089)   Mutation details: Using CRISPR/Cas9-based extreme genome editing, a p2A-creERT2-p2A-EGFP cassette was inserted between the last exon of the P2ry12 gene and its 3 UTR. (J:330602)

Activity:	Tissue activity of this recombinase allele
Driver:	P2ry12 (mouse) Summary of all recombinase alleles driven by P2ry12. Comparative matrix view of recombinase activities Alliance mouse P2ry12 gene page

In Mice Carrying this Mutation:

24 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any P2ry12 Mutation:	41 strains or lines available

Original:	J:330602 Zhou T, et al., Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice. Nat Commun. 2022 Oct 24;13(1):6233
All:	1 reference(s)