Agrptm4.1(cre/EGFP)Rpa
Targeted Allele Detail
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| Symbol: |
Agrptm4.1(cre/EGFP)Rpa |
| Name: |
agouti related neuropeptide; targeted mutation 4.1, Richard D Palmiter |
| MGI ID: |
MGI:7448510 |
| Synonyms: |
AgrpCre:GFP(version 2) |
| Gene: |
Agrp Location: Chr8:106293327-106306477 bp, - strand Genetic Position: Chr8, 53.04 cM, cytoband D1-D2
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| Alliance: |
Agrptm4.1(cre/EGFP)Rpa page
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| Allele Type: |
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Targeted (Epitope tag, Recombinase, Reporter) |
| Mutation: |
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Insertion
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Agrptm4.1(cre/EGFP)Rpa expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: The targeting construct introduced a cassette containing the following features, without the nuclear localization signal, using a nonoptimal initiation codon, a cre recombinase gene fused with EGFP (cre/EGFP) with N-term sequence removed, and a myc tag with an additional 3 untranslated region from the Myc gene that promotes a short messenger RNA half-life. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette introduced downstream of the fusion gene. It is a revised "version 2" of the allele Agrptm1.1(cre/EGFP)Stei designed to have an attenuated expression of Cre:GFP.
(J:295967)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Agrp
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Agrp Mutation: |
18 strains or lines available
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| Original: |
J:295967 Ewbank SN, et al., Chronic Gq signaling in AgRP neurons does not cause obesity. Proc Natl Acad Sci U S A. 2020 Aug 25;117(34):20874-20880 |
| All: |
1 reference(s) |
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Analysis Tools
