Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | Notes | References

Symbol:	Hnf4aem1(dre/ERT2)Bzsh
Name:	hepatic nuclear factor 4, alpha; endonuclease-mediated mutation 1, Bin Zhou
MGI ID:	MGI:7444938
Synonyms:	Hnf4a-DreER
Gene:	Hnf4a  Location: Chr2:163348731-163414827 bp, + strand  Genetic Position: Chr2, 84.32 cM
Alliance:	Hnf4aem1(dre/ERT2)Bzsh page

Germline Transmission:	Earliest citation of germline transmission: J:278017
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Endonuclease-mediated (Inducible, Recombinase) Mutation:    Insertion   Hnf4aem1(dre/ERT2)Bzsh expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Hnf4a (MGI:109128)   Mutation details: Using CRISPR/Cas9 methods, a cDNA encoding IRES-DreERT2 was inserted in-frame with the translation codon of the Hnf4a gene. The chimeric mice positive for targeted ESCs were germline transferred to F1 generation. (J:278017)

Activity:	Tissue activity of this recombinase allele
Driver:	Hnf4a (mouse) Summary of all recombinase alleles driven by Hnf4a. Comparative matrix view of recombinase activities Alliance mouse Hnf4a gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hnf4a Mutation:	27 strains or lines available

Original:	J:278017 Han X, et al., Lineage Tracing Reveals the Bipotency of SOX9(+) Hepatocytes during Liver Regeneration. Stem Cell Reports. 2019 Mar 5;12(3):624-638
All:	1 reference(s)