Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | Notes | References

Symbol:	Esm1em1(icre/ERT2)Ben
Name:	endothelial cell-specific molecule 1; endonuclease-mediated mutation 1, Rui Benedito
MGI ID:	MGI:7444426
Synonyms:	Esm1-HA-H2B-Cerulean-2A-CreERT2, Gt(Esm1)tm(HA-H2B-Cerulean-2A-CreERT2)
Gene:	Esm1  Location: Chr13:113346193-113354632 bp, + strand  Genetic Position: Chr13, 63.93 cM
Alliance:	Esm1em1(icre/ERT2)Ben page

Germline Transmission:	Earliest citation of germline transmission: J:275593
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Endonuclease-mediated (Epitope tag, Inducible, Recombinase, Reporter) Inducer:    tamoxifen Mutation:    Insertion   Esm1em1(icre/ERT2)Ben expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Esm1 (MGI:1918940)   Mutation details: Using CRISPR/Cas9-assisted homologous-dependent recombination in mouse ES cells, the HA-H2B-Cerulean-2A-iCreERT2 cassette was inserted in-frame with the endogenous Esm1 gene ATG initiation codon. (J:275593)

Activity:	Tissue activity of this recombinase allele
Driver:	Esm1 (mouse) Summary of all recombinase alleles driven by Esm1. Comparative matrix view of recombinase activities Alliance mouse Esm1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Esm1 Mutation:	16 strains or lines available

Original:	J:275593 Pontes-Quero S, et al., High mitogenic stimulation arrests angiogenesis. Nat Commun. 2019 May 1;10(1):2016
All:	1 reference(s)