About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:316179 Wang A, et al., An epigenetic circuit controls neurogenic programs during neocortex development. Development. 2021;148:dev199772
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7444004
Gene symbol: Sox2
Gene name: SRY (sex determining region Y)-box 2
Results
Specimen 4K SOX2 WT: postnatal adult (more )
Structure Cell Type Level Pattern Image Note
TS28: forebrain ventricular layer neural progenitor cell Present 4K WT (enlsrged) , 4K WT
TS28: telencephalon subventricular zone neural progenitor cell Present 4K WT (enlsrged) , 4K WT
Specimen 4K SOX2 KO: postnatal adult; Lncbarem1Bcgen/Lncbarem1Bcgen (more )
Structure Cell Type Level Pattern Image Note
TS28: forebrain ventricular layer neural progenitor cell Weak 4K KO , 4K KO (enlarged) Significantly fewer expressing cells in ventricular zone-subventricular zones of walls of lateral ventricles.
TS28: telencephalon subventricular zone neural progenitor cell Weak 4K KO , 4K KO (enlarged) Significantly fewer expressing cells in ventricular zone-subventricular zones of walls of lateral ventricles.
Specimen S5E SOX2 WT: postnatal adult (more )
Structure Cell Type Level Pattern Image Note
TS28: forebrain ventricular layer neural progenitor cell Present S5E WT (right) , S5E WT (left)
TS28: telencephalon subventricular zone neural progenitor cell Present S5E WT (right) , S5E WT (left)
Specimen S5E SOX2 KO: postnatal adult; Lncbarem1Bcgen/Lncbarem1Bcgen (more )
Structure Cell Type Level Pattern Image Note
TS28: forebrain ventricular layer neural progenitor cell Weak S5E KO (left) , S5E KO (right) Significantly fewer expressing cells in ventricular zone-subventricular zones of walls of lateral ventricles.
TS28: telencephalon subventricular zone neural progenitor cell Weak S5E KO (left) , S5E KO (right) Significantly fewer expressing cells in ventricular zone-subventricular zones of walls of lateral ventricles.
Specimen 4M SOX2 WT: embryonic day 16.5 (more )
Structure Cell Type Level Pattern Image Note
TS24: telencephalon neural progenitor cell Present 4M WT (enlarged) , 4M WT
Specimen 4M SOX2 KO: embryonic day 16.5; Lncbarem1Bcgen/Lncbarem1Bcgen (more )
Structure Cell Type Level Pattern Image Note
TS24: telencephalon neural progenitor cell Weak Regionally restricted 4M KO (enlarged) , 4M KO Significantly lower number of progenitor cells in both dorsal and ventral telencephalon.
Specimen 4O SOX2 WT: embryonic day 16.5 (more )
Structure Cell Type Level Pattern Image Note
TS24: telencephalon neural progenitor cell Present 4O WT (enlarged) , 4O WT
Specimen 4O SOX2 KO: embryonic day 16.5; Lncbarem1Bcgen/Lncbarem1Bcgen (more )
Structure Cell Type Level Pattern Image Note
TS24: telencephalon neural progenitor cell Weak 4O KO , 4O KO (enlarged) Significantly lower number of expressing cells in both dorsal and ventral telencephalon.
Specimen S5F SOX2 WT: embryonic day 16.5 (more )
Structure Cell Type Level Pattern Image Note
TS24: telencephalon neural progenitor cell Present S5F WT SOX2
TS24: cerebral cortex Present S5F WT cortex
TS24: allocortex Present S5F WT ventral
Specimen S5F SOX2 KO: embryonic day 16.5; Lncbarem1Bcgen/Lncbarem1Bcgen (more )
Structure Cell Type Level Pattern Image Note
TS24: telencephalon neural progenitor cell Weak S5F KO SOX2 Significantly lower number of expressing cells in both dorsal and ventral telencephalon.
TS24: cerebral cortex Weak S5F KO cortex
TS24: allocortex Weak S5F KO ventral
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory