Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Xcr1tm2.1(icre)Ciphe
Name:	chemokine (C motif) receptor 1; targeted mutation 2.1, Centre d'ImmunoPhenomique
MGI ID:	MGI:7442771
Synonyms:	Xcr1Cre-mTFP1, Xcr1-IRES-iCre-GSG-2A-mTFP1, Xcr1tm2Ciphe
Gene:	Xcr1  Location: Chr9:123681380-123691094 bp, - strand  Genetic Position: Chr9, 74.71 cM, cytoband F4
Alliance:	Xcr1tm2.1(icre)Ciphe page

Germline Transmission:	Earliest citation of germline transmission: J:327136
Parent Cell Line:	JM8.F6 (ES Cell)
Strain of Origin:	C57BL/6N

Allele Type:    Targeted (Recombinase, Reporter) Mutation:    Insertion   Xcr1tm2.1(icre)Ciphe expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Xcr1 (MGI:1346338)   Mutation details: A targeting construct was designed to introduce an IRES-iCre-GSG-2A-mTFP1 cassette in the 3 untranslated region of the Xcr1gene, 29base pair (bp) downstream of the stop codon. mTFP1 is the sequence coding for a monomeric, bright, and photostable version of Clavularia cyan fluorescent protein. After germline transmission, excision of the frt-neor-frt cassette was achieved through crossing with mice expressing an FLP recombinase (J:327136)

Activity:	Tissue activity of this recombinase allele
Driver:	Xcr1 (mouse) Summary of all recombinase alleles driven by Xcr1. Comparative matrix view of recombinase activities Alliance mouse Xcr1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Xcr1 Mutation:	32 strains or lines available

Original:	J:327136 Wohn C, et al., Absence of MHC class II on cDC1 dendritic cells triggers fatal autoimmunity to a cross-presented self-antigen. Sci Immunol. 2020 Mar 13;5(45):eaba1896
All:	8 reference(s)