Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Il25tm2.1(icre)Lky
Name:	interleukin 25; targeted mutation 2.1, Richard M Locksley
MGI ID:	MGI:7442196
Synonyms:	25Cre
Gene:	Il25  Location: Chr14:55170152-55173294 bp, + strand  Genetic Position: Chr14, 28.0 cM
Alliance:	Il25tm2.1(icre)Lky page

Germline Transmission:	Earliest citation of germline transmission: J:333765
Parent Cell Line:	PRX-B6T (ES Cell)
Strain of Origin:	C57BL/6J

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Il25tm2.1(icre)Lky expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Il25 (MGI:2155888)   Mutation details: A humanized (eukaryotic codon-optimized) Cre and an FRT flanked neo cassette were inserted in the 3'UTR via homologous recombination. Flp mediated recombination removed the neo cassette. (J:333765)

Activity:	Tissue activity of this recombinase allele
Driver:	Il25 (mouse) Summary of all recombinase alleles driven by Il25. Comparative matrix view of recombinase activities Alliance mouse Il25 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il25 Mutation:	14 strains or lines available

Original:	J:333765 O'Leary CE, et al., Bile acid-sensitive tuft cells regulate biliary neutrophil influx. Sci Immunol. 2022 Mar 4;7(69):eabj1080
All:	1 reference(s)