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Gene Expression Data
Assay Details
Assay
Reference: J:73592 Suda Y, et al., Otx1 function overlaps with Otx2 in development of mouse forebrain and midbrain. Genes Cells. 1996 Nov;1(11):1031-44
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7439855
Gene symbol: Nefm
Gene name: neurofilament, medium polypeptide
Results
Specimen 3C/E: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: cranial nerve Present 3C , 3E
Specimen 3D/F: embryonic day 10.5; Otx1tm1Sia/Otx1tm1Sia (more )
Structure Level Pattern Image Note
TS17: cranial nerve Present Regionally restricted 3F , 3D The number of mesencephalic trigeminal neurones was frequently diminished, and their axonal pathways were disturbed. Concomitantly the mesencephalic trigeminal root was sparse.
Specimen 4C: embryonic day 11.5; Otx2tm1Sia/Otx2+ (more )
Structure Level Pattern Image Note
TS19: cranial nerve Present 4C Similar as in the wild-type.
Specimen 4D: embryonic day 11.5; Otx1tm1Sia/Otx1+, Otx2tm1Sia/Otx2+ (more )
Note: majority (10 out of 13) with milder phenotype
Structure Level Pattern Image Note
TS19: cranial nerve Present 4D Cranial nerve development was also normal.
TS19: oculomotor nerve Present Regionally restricted 4D Fasciculation was very poor.
Specimen 4E: embryonic day 11.5; Otx1tm1Sia/Otx1+, Otx2tm1Sia/Otx2+ (more )
Note: minority (3 out of 13) with heavier phenotype
Structure Level Pattern Image Note
TS19: trigeminal nerve Present Regionally restricted 4E The ophthalmic branch was poorly fasciculated and even lost in severe cases. The maxillary and mandibular branches developed normally.
TS19: oculomotor nerve Present Regionally restricted 4E Fasciculation was very poor.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/30/2025
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