Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Pdgfctm2.1(cre/ERT2)Hdin
Name:	platelet-derived growth factor, C polypeptide; targeted mutation 2.1, Hao Ding
MGI ID:	MGI:7439353
Synonyms:	Pdgf-cCreERT2
Gene:	Pdgfc  Location: Chr3:80943723-81121347 bp, + strand  Genetic Position: Chr3, 35.73 cM
Alliance:	Pdgfctm2.1(cre/ERT2)Hdin page

Germline Transmission:	Earliest citation of germline transmission: J:257668
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Pdgfctm2.1(cre/ERT2)Hdin expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Pdgfc (MGI:1859631)   Mutation details: A FRT flanked SA-IRESbgeo cassette, and T2A-CreERT2 are inserted into exon 6 before the stop codon of the Pdgfc gene. The FRT flanked SA-IRESbgeo cassette was removed by Flpe-mediated recombination. (J:257668)

Activity:	Tissue activity of this recombinase allele
Driver:	Pdgfc (mouse) Summary of all recombinase alleles driven by Pdgfc. Comparative matrix view of recombinase activities Alliance mouse Pdgfc gene page

In Mice Carrying this Mutation:

4 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdgfc Mutation:	35 strains or lines available

Original:	J:257668 Wu X, et al., A Pdgf-c(CreERT2) knock-in mouse model for tracing PDGF-C cell lineages during development. Genesis. 2018 Feb;56(2)
All:	1 reference(s)